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Twist Bioscience
TWST

262 hedge funds and large institutions have $2.73B invested in Twist Bioscience in 2025 Q1 according to their latest regulatory filings, with 46 funds opening new positions, 92 increasing their positions, 79 reducing their positions, and 26 closing their positions.

New
Increased
Maintained
Reduced
Closed

77% more first-time investments, than exits

New positions opened: 46 | Existing positions closed: 26

60% more call options, than puts

Call options by funds: $3.36M | Put options by funds: $2.11M

50% more funds holding in top 10

Funds holding in top 10: 2 → 3 (+1)

16% more repeat investments, than reductions

Existing positions increased: 92 | Existing positions reduced: 79

7% more funds holding

Funds holding: 246 → 262 (+16)

5.19% more ownership

Funds ownership: 111.49% → 116.69% (+5.2%)

11% less capital invested

Capital invested by funds: $3.08B → $2.73B (-$351M)

Holders
262
Holders Change
+16
Holders Change %
+6.5%
% of All Funds
3.51%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.04%
New
46
Increased
92
Reduced
79
Closed
26
Calls
$3.36M
Puts
$2.11M
Net Calls
+$1.26M
Net Calls Change
-$2.71M

Top Buyers

1
UBS AM
UBS AM
Illinois
+$71.5M
2
Point72 Asset Management
Point72 Asset Management
Connecticut
+$64.5M
3
EIG
EdgePoint Investment Group
Ontario, Canada
+$50.1M
4
William Blair Investment Management
William Blair Investment Management
Illinois
+$38.6M
5
AIM
ARK Investment Management
Florida
+$29.1M

Top Sellers

1
Marshall Wace
Marshall Wace
United Kingdom
-$23.8M
2
FAM
Fred Alger Management
New York
-$19M
3
JP Morgan Chase
JP Morgan Chase
New York
-$15.6M
4
Citadel Advisors
Citadel Advisors
Florida
-$14.9M
5
Millennium Management
Millennium Management
New York
-$14.7M
Name Holding Trade Value Shares
Change 		Change in
Stake
AIM
1
ARK Investment Management
Florida
$245M +$29.1M +645,730 +12%
Vanguard Group
2
Vanguard Group
Pennsylvania
$230M +$2.71M +60,276 +1%
Artisan Partners
3
Artisan Partners
Wisconsin
$230M -$1.91M -42,307 -0.7%
BlackRock
4
BlackRock
New York
$221M +$2.42M +53,722 +1%
William Blair Investment Management
5
William Blair Investment Management
Illinois
$149M +$38.6M +857,144 +29%
Invesco
6
Invesco
Georgia
$133M -$9.02M -200,205 -6%
State Street
7
State Street
Massachusetts
$106M +$6.74M +149,677 +6%
UBS AM
8
UBS AM
Illinois
$95.9M +$71.5M +1,588,587 +186%
Sumitomo Mitsui Trust Group
9
Sumitomo Mitsui Trust Group
Japan
$94.8M -$8.88M -197,166 -8%
NAMA
10
Nikko Asset Management Americas
New York
$94.8M -$8.88M -197,166 -8%
Thrivent Financial for Lutherans
11
Thrivent Financial for Lutherans
Minnesota
$59.2M +$152K +3,384 +0.2%
JP Morgan Chase
12
JP Morgan Chase
New York
$57M -$15.6M -347,104 -19%
Point72 Asset Management
13
Point72 Asset Management
Connecticut
$56.3M +$64.5M +1,432,852 New
Geode Capital Management
14
Geode Capital Management
Massachusetts
$55.8M +$2.04M +45,272 +3%
FLAM
15
First Light Asset Management
Minnesota
$47.8M -$340K -7,556 -0.6%
EIG
16
EdgePoint Investment Group
Ontario, Canada
$43.7M +$50.1M +1,113,210 New
Citadel Advisors
17
Citadel Advisors
Florida
$42.1M -$14.9M -330,991 -24%
Goldman Sachs
18
Goldman Sachs
New York
$36.6M +$1.69M +37,577 +4%
TCM
19
Tao Capital Management
California
$32.5M – – –
N
20
Nuveen
North Carolina
$32M +$23.5M +521,417 +178%
American Century Companies
21
American Century Companies
Missouri
$30M +$318K +7,054 +0.9%
Wellington Management Group
22
Wellington Management Group
Massachusetts
$29.9M -$1.14M -25,361 -3%
Dimensional Fund Advisors
23
Dimensional Fund Advisors
Texas
$28.9M -$6.48M -143,851 -16%
Baillie Gifford & Co
24
Baillie Gifford & Co
United Kingdom
$28.7M -$2.05M -45,530 -6%
Northern Trust
25
Northern Trust
Illinois
$24.2M -$486K -10,785 -2%
1
2 3 4 5

TWST Hedge Fund Activity: Q1 2025 in Review

262 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Twist Bioscience (TWST) for Q1 2025, worth a combined $2.73B — down 11% from $3.08B a quarter earlier.

Buyers outnumbered sellers: 46 funds opened new TWST positions and 26 closed out — a net gain of 20 holders — while 92 added to existing stakes and 79 trimmed.

The largest buyer was UBS AM, adding an estimated $71.5M. The largest seller was Marshall Wace, cutting an estimated $23.8M.

  • 262 institutional investors held Twist Bioscience (TWST) as of Q1 2025, up from 246 in Q4 2024.
  • Funds reported $2.73B of Twist Bioscience stock for Q1 2025, down 11% quarter-over-quarter.
  • 46 funds opened new Twist Bioscience positions in Q1 2025 and 26 closed out, a net change of +20 holders.
  • The largest Twist Bioscience buyer in Q1 2025 was UBS AM, an estimated $71.5M added.
  • The largest Twist Bioscience seller in Q1 2025 was Marshall Wace, an estimated $23.8M sold.

Based on aggregated 13F filings for Q1 2025.