Twist Bioscience
TWST
244 hedge funds and large institutions have $2.38B invested in Twist Bioscience in 2025 Q4 according to their latest regulatory filings, with 48 funds opening new positions, 75 increasing their positions, 77 reducing their positions, and 38 closing their positions.
33% more funds holding in top 10
Funds holding in top 10: 3 → 4 (+1)
33% more call options, than puts
Call options by funds: $4.3M | Put options by funds: $3.25M
26% more first-time investments, than exits
New positions opened: 48 | Existing positions closed: 38
15% more capital invested
Capital invested by funds: $2.08B → $2.38B (+$304M)
2% more funds holding
Funds holding: 239 → 244 (+5)
0.46% more ownership
Funds ownership: 122.21% → 122.67% (+0.46%)
3% less repeat investments, than reductions
Existing positions increased: 75 | Existing positions reduced: 77
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
William Blair Investment Management
Chicago,
Illinois
|
+$56.5M |
| 2 |
EIG
EdgePoint Investment Group
Toronto,
Ontario, Canada
|
+$40.4M |
| 3 |
AIM
ARK Investment Management
St. Petersburg,
Florida
|
+$26M |
| 4 |
State Street
Boston,
Massachusetts
|
+$16.8M |
| 5 |
SC
Stempoint Capital
New York
|
+$16.2M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
JP Morgan Chase
New York
|
-$25.1M |
| 2 |
Morgan Stanley
New York
|
-$19.5M |
| 3 |
Artisan Partners
Milwaukee,
Wisconsin
|
-$18.1M |
| 4 |
Invesco
Atlanta,
Georgia
|
-$15.8M |
| 5 |
Point72 Asset Management
Stamford,
Connecticut
|
-$14.9M |
TWST Hedge Fund Activity: Q4 2025 in Review
244 of the 8,266 institutional investors tracked by Wall St. Rank reported a position in Twist Bioscience (TWST) for Q4 2025, worth a combined $2.38B — up 15% from $2.08B a quarter earlier.
Buyers outnumbered sellers: 48 funds opened new TWST positions and 38 closed out — a net gain of 10 holders — while 75 added to existing stakes and 77 trimmed.
The largest buyer was William Blair Investment Management, adding an estimated $56.5M. The largest seller was JP Morgan Chase, cutting an estimated $25.1M.
- 244 institutional investors held Twist Bioscience (TWST) as of Q4 2025, up from 239 in Q3 2025.
- Funds reported $2.38B of Twist Bioscience stock for Q4 2025, up 15% quarter-over-quarter.
- 48 funds opened new Twist Bioscience positions in Q4 2025 and 38 closed out, a net change of +10 holders.
- The largest Twist Bioscience buyer in Q4 2025 was William Blair Investment Management, an estimated $56.5M added.
- The largest Twist Bioscience seller in Q4 2025 was JP Morgan Chase, an estimated $25.1M sold.
Based on aggregated 13F filings for Q4 2025.