Twist Bioscience
TWST
242 hedge funds and large institutions have $2.08B invested in Twist Bioscience in 2025 Q3 according to their latest regulatory filings, with 34 funds opening new positions, 97 increasing their positions, 64 reducing their positions, and 35 closing their positions.
88% more call options, than puts
Call options by funds: $4.74M | Put options by funds: $2.51M
52% more repeat investments, than reductions
Existing positions increased: 97 | Existing positions reduced: 64
50% more funds holding in top 10
Funds holding in top 10: 2 → 3 (+1)
27% more capital inflows, than outflows
Capital inflows: $328M | Capital outflows: $259M
4.19% more ownership
Funds ownership: 113.44% → 117.63% (+4.2%)
3% less first-time investments, than exits
New positions opened: 34 | Existing positions closed: 35
2% less funds holding
Funds holding: 247 → 242 (-5)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
EdgePoint Investment Group
Toronto,
Ontario, Canada
|
+$51.4M |
| 2 |
Soleus Capital Management
Greenwich,
Connecticut
|
+$45.8M |
| 3 |
Artisan Partners
Milwaukee,
Wisconsin
|
+$40.9M |
| 4 |
Millennium Management
New York
|
+$32.7M |
| 5 |
State Street
Boston,
Massachusetts
|
+$17.8M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Point72 Asset Management
Stamford,
Connecticut
|
-$49.3M |
| 2 |
Citadel Advisors
Miami,
Florida
|
-$42M |
| 3 |
ExodusPoint Capital Management
New York
|
-$17.4M |
| 4 |
Invesco
Atlanta,
Georgia
|
-$16.7M |
| 5 |
Iron Triangle Partners
Cos Cob,
Connecticut
|
-$15.6M |
TWST Hedge Fund Activity: Q3 2025 in Review
242 of the 7,661 institutional investors tracked by Wall St. Rank reported a position in Twist Bioscience (TWST) for Q3 2025, worth a combined $2.08B — down 21% from $2.62B a quarter earlier.
Sellers outnumbered buyers: 35 funds closed out of TWST and 34 opened new positions — a net loss of 1 holder — while 64 trimmed existing stakes and 97 added.
The largest buyer was EdgePoint Investment Group, adding an estimated $51.4M. The largest seller was Point72 Asset Management, cutting an estimated $49.3M.
- 242 institutional investors held Twist Bioscience (TWST) as of Q3 2025, down from 247 in Q2 2025.
- Funds reported $2.08B of Twist Bioscience stock for Q3 2025, down 21% quarter-over-quarter.
- 34 funds opened new Twist Bioscience positions in Q3 2025 and 35 closed out, a net change of -1 holder.
- The largest Twist Bioscience buyer in Q3 2025 was EdgePoint Investment Group, an estimated $51.4M added.
- The largest Twist Bioscience seller in Q3 2025 was Point72 Asset Management, an estimated $49.3M sold.
Based on aggregated 13F filings for Q3 2025.