|
1
|
RA Capital Management
Boston,
Massachusetts
|
$130M
|
–
|
–
|
–
|
|
|
2
|
Avoro Capital Advisors
New York
|
$119M
|
–
|
–
|
–
|
|
|
3
|
|
$103M
|
+$11.1M
|
+2,278,268
|
+14%
|
|
|
4
|
|
$99.4M
|
-$5.97M
|
-1,229,085
|
-6%
|
|
|
5
|
|
$90.2M
|
-$38.6M
|
-7,955,994
|
-33%
|
|
|
6
|
Vestal Point Capital
New York
|
$75.6M
|
+$40.1M
|
+8,250,000
|
+150%
|
|
|
7
|
|
$75.3M
|
+$1.5M
|
+309,031
|
+2%
|
|
|
8
|
Fidelity Investments
Boston,
Massachusetts
|
$74.4M
|
-$5.17M
|
-1,065,046
|
-7%
|
|
|
9
|
Vanguard Group
Malvern,
Pennsylvania
|
$73M
|
+$2.03M
|
+418,192
|
+3%
|
|
|
10
|
State Street
Boston,
Massachusetts
|
$59.3M
|
+$17.3M
|
+3,553,619
|
+49%
|
|
|
11
|
Siren LLC
Greenwich,
Connecticut
|
$55.7M
|
-$4.3M
|
-884,824
|
-8%
|
|
|
12
|
Octagon Capital Advisors
New York
|
$48.7M
|
-$1.01M
|
-207,589
|
-2%
|
|
|
13
|
Polar Capital Holdings
London,
United Kingdom
|
$43.6M
|
+$12.8M
|
+2,637,524
|
+50%
|
|
|
14
|
Barclays
London,
United Kingdom
|
$30.5M
|
+$1.9M
|
+390,889
|
+8%
|
|
|
15
|
Geode Capital Management
Boston,
Massachusetts
|
$29.6M
|
+$1.03M
|
+212,510
|
+4%
|
|
|
16
|
|
$22.1M
|
+$6.35M
|
+1,307,201
|
+48%
|
|
|
17
|
Baker Bros. Advisors
New York
|
$22M
|
–
|
–
|
–
|
|
|
18
|
Point72 Asset Management
Stamford,
Connecticut
|
$21.3M
|
-$16.8M
|
-3,462,788
|
-47%
|
|
|
19
|
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Toronto,
Ontario, Canada
|
$20.5M
|
+$18.1M
|
+3,722,000
|
New
|
|
|
20
|
Affinity Asset Advisors
New York
|
$18.1M
|
+$1.46M
|
+300,000
|
+10%
|
|
|
21
|
Millennium Management
New York
|
$17.5M
|
-$4.11M
|
-847,259
|
-21%
|
|
|
22
|
Deerfield Management
New York
|
$15M
|
-$12.9M
|
-2,663,835
|
-49%
|
|
|
23
|
ADAR1 Capital Management
Austin,
Texas
|
$13.7M
|
-$1.65M
|
-339,871
|
-12%
|
|
|
24
|
Charles Schwab
San Francisco,
California
|
$10.5M
|
+$274K
|
+56,468
|
+3%
|
|
|
25
|
Citadel Advisors
Miami,
Florida
|
$10.2M
|
+$7.22M
|
+1,487,546
|
+405%
|
|
