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Taysha Gene Therapies
TSHA

Overview Fund Activity

147 hedge funds and large institutions have $595M invested in Taysha Gene Therapies in 2025 Q2 according to their latest regulatory filings, with 44 funds opening new positions, 48 increasing their positions, 32 reducing their positions, and 19 closing their positions.

Holders
147
Holders Change
+22
Holders Change %
+17.6%
% of All Funds
1.97%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.04%
New
44
Increased
48
Reduced
32
Closed
19
Calls
$249K
Puts
$47K
Net Calls
+$202K
Net Calls Change
+$65K

Top Buyers

1
RCM
1
RA Capital Management
Massachusetts
$54.4M
2
Goldman Sachs
2
Goldman Sachs
New York
$29.1M
3
JFG
3
Jefferies Financial Group
New York
$23.8M
4
RI
4
RTW Investments
New York
$57.8M
5
DM
5
Deerfield Management
New York
$12.4M

Top Sellers

1
JPMorgan Chase & Co
1
JPMorgan Chase & Co
New York
$514K
2
GIM
2
Granahan Investment Management
Massachusetts
$2.21M
3
SCM
3
Superstring Capital Management
New York
$0
4
DCM
4
DAFNA Capital Management
California
$0
5
BlackRock
5
BlackRock
New York
$30.7M
Name Market Value Shares Shares
Change 		Shares
Change %
RI
1
RTW Investments
New York
$57.8M 25,021,584 +6,233,718 +33%
RCM
2
RA Capital Management
Massachusetts
$54.4M 23,555,648 +12,683,145 +117%
ACA
3
Avoro Capital Advisors
New York
$50.1M 21,700,000 +1,700,001 +9%
Morgan Stanley
4
Morgan Stanley
New York
$39M 16,865,082 +18,708 +0.1%
Fidelity Investments
5
Fidelity Investments
Massachusetts
$36.1M 15,627,822 -4,132 -0%
BlackRock
6
BlackRock
New York
$30.7M 13,303,775 -285,403 -2%
OCA
7
Octagon Capital Advisors
New York
$29.1M 12,592,500 +1,892,500 +18%
Goldman Sachs
8
Goldman Sachs
New York
$29.1M 12,587,700 +12,228,693 +3,406%
SL
9
Siren LLC
Connecticut
$25.4M 11,014,737 +4,500,000 +69%
Vanguard Group
10
Vanguard Group
Pennsylvania
$25.2M 10,894,127 +2,123,206 +24%
JFG
11
Jefferies Financial Group
New York
$23.8M 10,313,733 +10,068,479 +4,105%
Point72 Asset Management
12
Point72 Asset Management
Connecticut
$16.9M 7,317,614 +2,747,936 +60%
DM
13
Deerfield Management
New York
$12.4M 5,386,000 +5,386,000 New
State Street
14
State Street
Massachusetts
$11.9M 5,138,310 +1,904,798 +59%
PCH
15
Polar Capital Holdings
United Kingdom
$11.6M 5,000,000 +2,000,000 +67%
Adage Capital Partners
16
Adage Capital Partners
Massachusetts
$11.2M 4,839,000 +4,839,000 New
Toronto Dominion Bank
17
Toronto Dominion Bank
Ontario, Canada
$10.9M 4,728,806 +4,728,806 New
TCM
18
Tybourne Capital Management
Hong Kong
$9.46M 4,095,000 +395,000 +11%
BBA
19
Baker Bros. Advisors
New York
$9.25M 4,004,756 – –
Geode Capital Management
20
Geode Capital Management
Massachusetts
$8.77M 3,793,572 +128,840 +4%
SCM
21
Suvretta Capital Management
New York
$7.43M 3,217,449 +3,217,449 New
ACM
22
ADAR1 Capital Management
Texas
$6.95M 3,009,870 +1,943,561 +182%
VPC
23
Vestal Point Capital
New York
$6.93M 3,000,000 +3,000,000 New
MB
24
MPM BioImpact
Massachusetts
$6.82M 2,953,562 +2,953,562 New
Millennium Management
25
Millennium Management
New York
$6.78M 2,935,728 +1,163,074 +66%
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