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Taysha Gene Therapies

191 hedge funds and large institutions have $1.21B invested in Taysha Gene Therapies in 2026 Q1 according to their latest regulatory filings, with 35 funds opening new positions, 69 increasing their positions, 49 reducing their positions, and 34 closing their positions.

New
Increased
Maintained
Reduced
Closed

356% more call options, than puts

Call options by funds: $1.61M | Put options by funds: $354K

41% more repeat investments, than reductions

Existing positions increased: 69 | Existing positions reduced: 49

3% more first-time investments, than exits

New positions opened: 35 | Existing positions closed: 34

2% less funds holding

Funds holding: 195191 (-4)

5.73% less ownership

Funds ownership: 98.2%92.47% (-5.7%)

19% less capital invested

Capital invested by funds: $1.48B → $1.21B (-$274M)

50% less funds holding in top 10

Funds holding in top 10: 63 (-3)

Holders
191
Holders Change
-4
Holders Change %
-2.05%
% of All Funds
2.35%
Holding in Top 10
3
Holding in Top 10 Change
-3
Holding in Top 10 Change %
-50%
% of All Funds
0.04%
New
35
Increased
69
Reduced
49
Closed
34
Calls
$1.61M
Puts
$354K
Net Calls
+$1.26M
Net Calls Change
-$3.64M
Name Holding Trade Value Shares
Change
Change in
Stake
RCM
1
RA Capital Management
Massachusetts
$105M
Goldman Sachs
2
Goldman Sachs
New York
$100M +$40.3M +8,676,906 +63%
ACA
3
Avoro Capital Advisors
New York
$97M
BlackRock
4
BlackRock
New York
$82.1M -$1.29M -277,521 -1%
VPC
5
Vestal Point Capital
New York
$80.5M +$19.8M +4,250,000 +31%
Morgan Stanley
6
Morgan Stanley
New York
$80.3M -$526K -113,147 -0.6%
Fidelity Investments
7
Fidelity Investments
Massachusetts
$64M +$3.69M +792,889 +6%
RI
8
RTW Investments
New York
$61.2M -$12.6M -2,718,049 -17%
State Street
9
State Street
Massachusetts
$50.1M +$1.95M +418,994 +4%
VCM
10
Vanguard Capital Management
Pennsylvania
$45.7M +$47.6M +10,231,502 New
OCA
11
Octagon Capital Advisors
New York
$39.6M
SL
12
Siren LLC
Connecticut
$39.5M -$6.04M -1,300,000 -13%
PCH
13
Polar Capital Holdings
United Kingdom
$25.3M -$10.6M -2,277,063 -29%
Geode Capital Management
14
Geode Capital Management
Massachusetts
$24.7M +$674K +144,929 +3%
GGI
15
GordonMD Global Investments
California
$22.2M -$2.76M -593,351 -45%
D.E. Shaw & Co
16
D.E. Shaw & Co
New York
$19.8M +$1.92M +413,666 +10%
BBA
17
Baker Bros. Advisors
New York
$17.9M
Millennium Management
18
Millennium Management
New York
$14.7M +$479K +102,957 +3%
CC
19
Casdin Capital
New York
$14.5M +$8.14M +1,750,000 +117%
ACM
20
ADAR1 Capital Management
Texas
$13.3M +$2.25M +483,620 +19%
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
21
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$12.9M -$3.9M -838,699 -23%
DM
22
Deerfield Management
New York
$12.2M
Barclays
23
Barclays
United Kingdom
$11.4M -$12.7M -2,726,991 -49%
SG Americas Securities
24
SG Americas Securities
New York
$9.73M +$6.49M +1,395,268 +179%
VPM
25
Vanguard Portfolio Management
Pennsylvania
$9.04M +$9.4M +2,022,498 New