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Taysha Gene Therapies
TSHA

Overview Fund Activity

125 hedge funds and large institutions have $232M invested in Taysha Gene Therapies in 2025 Q1 according to their latest regulatory filings, with 22 funds opening new positions, 38 increasing their positions, 31 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
125
Holders Change
-4
Holders Change %
-3.1%
% of All Funds
1.7%
Holding in Top 10
2
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+100%
% of All Funds
0.03%
New
22
Increased
38
Reduced
31
Closed
25
Calls
$144K
Puts
$7K
Net Calls
+$137K
Net Calls Change
-$32K

Top Buyers

1
RI
RTW Investments
New York
+$14.1M
2
Point72 Asset Management
Point72 Asset Management
Connecticut
+$6.35M
3
Millennium Management
Millennium Management
New York
+$2.25M
4
ACM
ADAR1 Capital Management
Texas
+$1.24M
5
SCM
Superstring Capital Management
New York
+$1.05M

Top Sellers

1
Adage Capital Partners
Adage Capital Partners
Massachusetts
-$8.65M
2
VA
VR Adviser
New York
-$5.58M
3
State Street
State Street
Massachusetts
-$4.5M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
-$2.28M
5
ACP
Acuta Capital Partners
California
-$1.53M
Name Holding Trade Value Shares
Change 		Shares
Change %
ACA
1
Avoro Capital Advisors
New York
$27.8M – – –
RI
2
RTW Investments
New York
$26.1M +$14.1M +10,115,236 +117%
Morgan Stanley
3
Morgan Stanley
New York
$23.4M -$1.1M -793,992 -5%
Fidelity Investments
4
Fidelity Investments
Massachusetts
$21.7M -$1.02M -733,710 -4%
BlackRock
5
BlackRock
New York
$18.9M +$80.2K +57,711 +0.4%
RCM
6
RA Capital Management
Massachusetts
$15.1M – – –
OCA
7
Octagon Capital Advisors
New York
$14.9M +$348K +250,000 +2%
Vanguard Group
8
Vanguard Group
Pennsylvania
$12.2M -$189K -135,843 -2%
SL
9
Siren LLC
Connecticut
$9.06M -$122K -87,738 -1%
Point72 Asset Management
10
Point72 Asset Management
Connecticut
$6.35M +$6.35M +4,569,678 New
BBA
11
Baker Bros. Advisors
New York
$5.57M – – –
TCM
12
Tybourne Capital Management
Hong Kong
$5.14M – – –
Geode Capital Management
13
Geode Capital Management
Massachusetts
$5.1M +$128K +92,383 +3%
State Street
14
State Street
Massachusetts
$4.49M -$4.5M -3,240,855 -50%
PCH
15
Polar Capital Holdings
United Kingdom
$4.17M – – –
Millennium Management
16
Millennium Management
New York
$2.46M +$2.25M +1,621,040 +1,069%
GIM
17
Granahan Investment Management
Massachusetts
$2.28M +$6.13K +4,412 +0.3%
Northern Trust
18
Northern Trust
Illinois
$1.99M -$37.6K -27,066 -2%
PAI
19
Palo Alto Investors
California
$1.97M +$845K +608,200 +75%
BGI
20
B Group Inc
Texas
$1.75M +$403K +290,000 +30%
ACM
21
ADAR1 Capital Management
Texas
$1.48M +$1.24M +888,602 +500%
JPMorgan Chase & Co
22
JPMorgan Chase & Co
New York
$1.39M -$2.28M -1,640,688 -62%
WP
23
Woodline Partners
California
$1.19M -$235K -169,268 -16%
QPW
24
Quantum Private Wealth
Florida
$1.1M -$4.87K -3,500 -0.4%
SCM
25
Superstring Capital Management
New York
$1.05M +$1.05M +755,599 New
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