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SPRB

Spruce Biosciences
SPRB

32 hedge funds and large institutions have $48.3M invested in Spruce Biosciences in 2026 Q1 according to their latest regulatory filings, with 10 funds opening new positions, 6 increasing their positions, 6 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

11% more first-time investments, than exits

New positions opened: 10 | Existing positions closed: 9

0% more funds holding

Funds holding: 32 → 32 (0)

0% more funds holding in top 10

Funds holding in top 10: 1 → 1 (0)

0% more repeat investments, than reductions

Existing positions increased: 6 | Existing positions reduced: 6

16.51% less ownership

Funds ownership: 70.43% → 53.92% (-17%)

26% less capital invested

Capital invested by funds: $65.6M → $48.3M (-$17.3M)

Holders
32
Holders Change
–
Holders Change %
0%
% of All Funds
0.39%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
10
Increased
6
Reduced
6
Closed
9
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

Rank Fund Capital Flow
1
Millennium Management
Millennium Management
New York
+$7.72M
2
DP
Diadema Partners
New Jersey
+$690K
3
SC
Stempoint Capital
New York
+$439K
4
Goldman Sachs
Goldman Sachs
New York
+$380K
5
QOP
Quinn Opportunity Partners
Virginia
+$276K

Top Sellers

Rank Fund Capital Flow
1
SCM
Squadron Capital Management
Illinois
-$3.99M
2
SSA
Schonfeld Strategic Advisors
New York
-$2.16M
3
CP
Caligan Partners
New York
-$1.79M
4
SCM
Stonepine Capital Management
Oregon
-$1.72M
5
SCM
Superstring Capital Management
New York
-$1.06M
Name Holding Trade Value Shares
Change 		Change in
Stake
Citigroup
26
Citigroup
New York
$61.4K +$64.8K +939 New
Vanguard Global Advisers
27
Vanguard Global Advisers
Pennsylvania
$29.5K +$31.2K +452 New
SIS
28
Sound Income Strategies
Florida
$13.9K – – –
Jones Financial Companies
29
Jones Financial Companies
Missouri
$12.2K +$7.52K +109 +130%
TRCT
30
Tower Research Capital (TRC)
New York
$9.15K +$9.59K +139 +13,900%
CSC
31
Caldwell Sutter Capital
California
$850 – – –
CCWM
32
Cassaday & Co Wealth Management
Virginia
$130 +$138 +2 New
SSA
33
Schonfeld Strategic Advisors
New York
– -$2.16M -24,767 Closed
CP
34
Caligan Partners
New York
– -$1.79M -20,514 Closed
SCM
35
Stonepine Capital Management
Oregon
– -$1.72M -19,742 Closed
SCM
36
Superstring Capital Management
New York
– -$1.06M -12,137 Closed
SIA
37
SkyView Investment Advisors
New Jersey
– -$261K -3,000 Closed
Northern Trust
38
Northern Trust
Illinois
– -$211K -2,422 Closed
BNP Paribas Financial Markets
39
BNP Paribas Financial Markets
France
– -$174K -2,000 Closed
Bank of America
40
Bank of America
North Carolina
– -$8.1K -93 Closed
Royal Bank of Canada
41
Royal Bank of Canada
Ontario, Canada
– -$3K -40 Closed
1
2

SPRB Hedge Fund Activity: Q1 2026 in Review

32 of the 8,169 institutional investors tracked by Wall St. Rank reported a position in Spruce Biosciences (SPRB) for Q1 2026, worth a combined $48.3M — down 26% from $65.6M a quarter earlier.

Buyers outnumbered sellers: 10 funds opened new SPRB positions and 9 closed out — a net gain of 1 holder — while 6 added to existing stakes and 6 trimmed.

The largest buyer was Millennium Management, opening a new position worth an estimated $7.72M. The largest seller was Squadron Capital Management, cutting an estimated $3.99M.

  • 32 institutional investors held Spruce Biosciences (SPRB) as of Q1 2026, unchanged from Q4 2025.
  • Funds reported $48.3M of Spruce Biosciences stock for Q1 2026, down 26% quarter-over-quarter.
  • 10 funds opened new Spruce Biosciences positions in Q1 2026 and 9 closed out, a net change of +1 holder.
  • The largest Spruce Biosciences buyer in Q1 2026 was Millennium Management, an estimated $7.72M added.
  • The largest Spruce Biosciences seller in Q1 2026 was Squadron Capital Management, an estimated $3.99M sold.

Based on aggregated 13F filings for Q1 2026.