Spruce Biosciences
SPRB
32 hedge funds and large institutions have $65.6M invested in Spruce Biosciences in 2025 Q4 according to their latest regulatory filings, with 25 funds opening new positions, 4 increasing their positions, 1 reducing their positions, and 2 closing their positions.
1,150% more first-time investments, than exits
New positions opened: 25 | Existing positions closed: 2
300% more repeat investments, than reductions
Existing positions increased: 4 | Existing positions reduced: 1
256% more funds holding
Funds holding: 9 → 32 (+23)
161% more capital invested
Capital invested by funds: $25.1M → $65.6M (+$40.5M)
0% more funds holding in top 10
Funds holding in top 10: 1 → 1 (0)
451.36% less ownership
Funds ownership: 521.79% → 70.43% (-451%)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
IC
Ikarian Capital
Dallas,
Texas
|
+$11.6M |
| 2 |
Citadel Advisors
Miami,
Florida
|
+$7.5M |
| 3 |
Wellington Management Group
Boston,
Massachusetts
|
+$6.32M |
| 4 |
ACM
ADAR1 Capital Management
Austin,
Texas
|
+$6.21M |
| 5 |
Alyeska Investment Group
Chicago,
Illinois
|
+$5.54M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
CG
Carlyle Group
Washington,
District of Columbia
|
-$306M |
| 2 |
CCC
Cable Car Capital
San Francisco,
California
|
-$239K |
| 3 |
Osaic Holdings
Scottsdale,
Arizona
|
-$931 |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
26
Morgan Stanley
New York
| $33.8K | +$31.1K | +290 | +296% |
|
|
SIS
27
Sound Income Strategies
Ft Lauderdale,
Florida
| $14.7K | +$21.4K | +200 | New |
|
28
Bank of America
Charlotte,
North Carolina
| $8.1K | +$9.64K | +90 | +3,000% |
|
29
Jones Financial Companies
Des Peres,
Missouri
| $7.32K | +$9K | +84 | New |
|
30
Royal Bank of Canada
Toronto,
Ontario, Canada
| $3K | +$4.29K | +40 | New |
|
|
CSC
31
Caldwell Sutter Capital
Sausalito,
California
| $1.13K | – | – | – |
|
|
TRCT
32
Tower Research Capital (TRC)
New York
| $87 | +$107 | +1 | New |
|
|
CCC
33
Cable Car Capital
San Francisco,
California
| – | -$239K | -26,666 | Closed |
|
|
34
Osaic Holdings
Scottsdale,
Arizona
| – | -$931 | -133 | Closed |
|
SPRB Hedge Fund Activity: Q4 2025 in Review
32 of the 8,252 institutional investors tracked by Wall St. Rank reported a position in Spruce Biosciences (SPRB) for Q4 2025, worth a combined $65.6M — up 161% from $25.1M a quarter earlier.
Buyers outnumbered sellers: 25 funds opened new SPRB positions and 2 closed out — a net gain of 23 holders — while 4 added to existing stakes and 1 trimmed.
The largest buyer was Ikarian Capital, adding an estimated $11.6M. The largest seller was Carlyle Group, cutting an estimated $306M.
- 32 institutional investors held Spruce Biosciences (SPRB) as of Q4 2025, up from 9 in Q3 2025.
- Funds reported $65.6M of Spruce Biosciences stock for Q4 2025, up 161% quarter-over-quarter.
- 25 funds opened new Spruce Biosciences positions in Q4 2025 and 2 closed out, a net change of +23 holders.
- The largest Spruce Biosciences buyer in Q4 2025 was Ikarian Capital, an estimated $11.6M added.
- The largest Spruce Biosciences seller in Q4 2025 was Carlyle Group, an estimated $306M sold.
Based on aggregated 13F filings for Q4 2025.