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SLRN

ACELYRIN
SLRN

Delisted

SLRN was delisted on the 21st of May, 2025.

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110 hedge funds and large institutions have $639M invested in ACELYRIN in 2023 Q4 according to their latest regulatory filings, with 35 funds opening new positions, 31 increasing their positions, 28 reducing their positions, and 24 closing their positions.

New
Increased
Maintained
Reduced
Closed

866% more call options, than puts

Call options by funds: $4.96M | Put options by funds: $513K

46% more first-time investments, than exits

New positions opened: 35 | Existing positions closed: 24

11% more repeat investments, than reductions

Existing positions increased: 31 | Existing positions reduced: 28

9% more funds holding

Funds holding: 101 → 110 (+9)

1.84% more ownership

Funds ownership: 86.18% → 88.02% (+1.8%)

14% less funds holding in top 10

Funds holding in top 10: 7 → 6 (-1)

25% less capital invested

Capital invested by funds: $847M → $639M (-$208M)

Holders
110
Holders Change
+9
Holders Change %
+8.91%
% of All Funds
1.6%
Holding in Top 10
6
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-14.29%
% of All Funds
0.09%
New
35
Increased
31
Reduced
28
Closed
24
Calls
$4.96M
Puts
$513K
Net Calls
+$4.45M
Net Calls Change
+$6.94M

Top Buyers

Rank Fund Capital Flow
1
Vanguard Group
Vanguard Group
Pennsylvania
+$25.3M
2
BOCH
Blue Owl Capital Holdings
New York
+$19.6M
3
Morgan Stanley
Morgan Stanley
New York
+$12.9M
4
LGM
Logos Global Management
California
+$10.7M
5
BlackRock
BlackRock
New York
+$6.05M

Top Sellers

Rank Fund Capital Flow
1
EC
EcoR1 Capital
California
-$14.3M
2
DCM
Driehaus Capital Management
Illinois
-$13.4M
3
O
OrbiMed
New York
-$11.3M
4
State Street
State Street
Massachusetts
-$11.2M
5
IC
Ikarian Capital
Texas
-$7.92M
Name Holding Trade Value Shares
Change 		Change in
Stake
Franklin Resources
26
Franklin Resources
California
$6.01M – – –
Geode Capital Management
27
Geode Capital Management
Massachusetts
$5.78M +$558K +65,351 +9%
State Street
28
State Street
Massachusetts
$4.96M -$11.2M -1,315,378 -66%
SC
29
Stempoint Capital
New York
$4.38M +$5.01M +587,373 New
Walleye Capital
30
Walleye Capital
New York
$4.31M +$1.11M +130,137 +29%
KCM
31
Kennedy Capital Management
Missouri
$3.54M +$4.05M +474,006 New
Point72 Asset Management
32
Point72 Asset Management
Connecticut
$3.32M +$2.44M +286,192 +180%
DCM
33
DAFNA Capital Management
California
$2.77M +$3.11M +363,900 +4,985%
EAM
34
Eagle Asset Management
Florida
$2.68M +$3.17K +371 +0.1%
SCM
35
Superstring Capital Management
New York
$2.66M +$3.05M +356,924 New
SAM
36
Sectoral Asset Management
Quebec, Canada
$2.43M +$2.78M +325,549 New
Vontobel Holding
37
Vontobel Holding
Switzerland
$2.43M +$2.78M +325,549 New
Northern Trust
38
Northern Trust
Illinois
$2.17M +$89.4K +10,480 +4%
Charles Schwab
39
Charles Schwab
California
$1.85M +$33.6K +3,934 +2%
Adage Capital Partners
40
Adage Capital Partners
Massachusetts
$1.34M +$683K +80,000 +80%
CSS
41
Cubist Systematic Strategies
Connecticut
$1.19M +$1.36M +158,967 New
PE
42
Point72 Europe
United Kingdom
$917K +$1.05M +122,971 New
Voloridge Investment Management
43
Voloridge Investment Management
Florida
$773K +$885K +103,677 New
BFM
44
Boothbay Fund Management
New York
$749K +$856K +100,346 New
Ameriprise
45
Ameriprise
Minnesota
$721K +$244K +28,618 +42%
Bank of New York Mellon
46
Bank of New York Mellon
New York
$714K +$25.7K +3,009 +3%
LIP
47
Lighthouse Investment Partners
Florida
$646K +$740K +86,651 New
Bank of America
48
Bank of America
North Carolina
$621K -$1.21M -141,989 -63%
Prudential Financial
49
Prudential Financial
New Jersey
$585K +$670K +78,443 New
GCM
50
Ghisallo Capital Management
Massachusetts
$522K – – –
1
2
3 4 5

SLRN Hedge Fund Activity: Q4 2023 in Review

110 of the 6,859 institutional investors tracked by Wall St. Rank reported a position in ACELYRIN (SLRN) for Q4 2023, worth a combined $639M — down 25% from $847M a quarter earlier.

Buyers outnumbered sellers: 35 funds opened new SLRN positions and 24 closed out — a net gain of 11 holders — while 31 added to existing stakes and 28 trimmed.

The largest buyer was Vanguard Group, adding an estimated $25.3M. The largest seller was EcoR1 Capital, exiting entirely with an estimated $14.3M sold.

  • 110 institutional investors held ACELYRIN (SLRN) as of Q4 2023, up from 101 in Q3 2023.
  • Funds reported $639M of ACELYRIN stock for Q4 2023, down 25% quarter-over-quarter.
  • 35 funds opened new ACELYRIN positions in Q4 2023 and 24 closed out, a net change of +11 holders.
  • The largest ACELYRIN buyer in Q4 2023 was Vanguard Group, an estimated $25.3M added.
  • The largest ACELYRIN seller in Q4 2023 was EcoR1 Capital, an estimated $14.3M sold.

Based on aggregated 13F filings for Q4 2023.