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SLN

Silence Therapeutics
SLN

54 hedge funds and large institutions have $96.4M invested in Silence Therapeutics in 2025 Q3 according to their latest regulatory filings, with 6 funds opening new positions, 15 increasing their positions, 16 reducing their positions, and 7 closing their positions.

New
Increased
Maintained
Reduced
Closed

0% more funds holding in top 10

Funds holding in top 10: 2 → 2 (0)

0.18% less ownership

Funds ownership: 66.02% → 65.84% (-0.18%)

6% less repeat investments, than reductions

Existing positions increased: 15 | Existing positions reduced: 16

2% less funds holding

Funds holding: 55 → 54 (-1)

11% less capital invested

Capital invested by funds: $108M → $96.4M (-$11.6M)

14% less first-time investments, than exits

New positions opened: 6 | Existing positions closed: 7

100% less call options, than puts

Call options by funds: $0 | Put options by funds: $6K

Holders
54
Holders Change
-1
Holders Change %
-1.82%
% of All Funds
0.71%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
6
Increased
15
Reduced
16
Closed
7
Calls
–
Puts
$6K
Net Calls
-$6K
Net Calls Change
-$131K

Top Buyers

Rank Fund Capital Flow
1
Millennium Management
Millennium Management
New York
+$555K
2
UBS Group
UBS Group
Switzerland
+$438K
3
BFM
Boothbay Fund Management
New York
+$151K
4
IC
Ikarian Capital
Texas
+$151K
5
Goldman Sachs
Goldman Sachs
New York
+$126K

Top Sellers

Rank Fund Capital Flow
1
BlackRock
BlackRock
New York
-$591K
2
Marshall Wace
Marshall Wace
United Kingdom
-$515K
3
Jane Street
Jane Street
New York
-$219K
4
SVCM
Saturn V Capital Management
Texas
-$201K
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
-$161K
Name Holding Trade Value Shares
Change 		Change in
Stake
TCM
1
TCG Crossover Management
California
$15.7M – – –
SL
2
Siren LLC
Connecticut
$15.1M – – –
RG
3
Redmile Group
California
$11.2M – – –
LOAMU
4
Lombard Odier Asset Management (USA)
New York
$7.12M -$26.6K -4,786 -0.3%
Morgan Stanley
5
Morgan Stanley
New York
$6.27M -$22.4K -4,034 -0.3%
VC
6
Vivo Capital
California
$5.74M – – –
NCM
7
Nantahala Capital Management
Connecticut
$5.41M – – –
FLSM
8
Frazier Life Sciences Management
California
$5.03M – – –
NI
9
Nextech Invest
Switzerland
$4.94M – – –
CF
10
Cantor Fitzgerald
New York
$4.16M +$68.1K +12,267 +2%
5VM
11
5AM Venture Management
California
$2.47M – – –
SG Americas Securities
12
SG Americas Securities
New York
$1.6M -$233 -42 -0%
UBS Group
13
UBS Group
Switzerland
$1.6M +$438K +78,854 +35%
Millennium Management
14
Millennium Management
New York
$1.55M +$555K +99,865 +50%
BFM
15
Boothbay Fund Management
New York
$1.45M +$151K +27,216 +11%
IC
16
Ikarian Capital
Texas
$1.31M +$151K +27,216 +3%
MCM
17
M28 Capital Management
Connecticut
$961K – – –
HSBC Holdings
18
HSBC Holdings
United Kingdom
$909K +$217 +39 +0%
Bank of Montreal
19
Bank of Montreal
Ontario, Canada
$798K +$44.3K +7,970 +5%
Marshall Wace
20
Marshall Wace
United Kingdom
$432K -$515K -92,643 -53%
Two Sigma Investments
21
Two Sigma Investments
New York
$328K +$21.9K +3,935 +7%
WP
22
Woodline Partners
California
$324K – – –
BlackRock
23
BlackRock
New York
$321K -$591K -106,403 -63%
Osaic Holdings
24
Osaic Holdings
Arizona
$299K -$40K -7,210 -10%
Two Sigma Advisers
25
Two Sigma Advisers
New York
$221K +$16.7K +3,000 +8%
1
2 3

SLN Hedge Fund Activity: Q3 2025 in Review

54 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Silence Therapeutics (SLN) for Q3 2025, worth a combined $96.4M — down 11% from $108M a quarter earlier.

Sellers outnumbered buyers: 7 funds closed out of SLN and 6 opened new positions — a net loss of 1 holder — while 16 trimmed existing stakes and 15 added.

The largest buyer was Millennium Management, adding an estimated $555K. The largest seller was BlackRock, cutting an estimated $591K.

  • 54 institutional investors held Silence Therapeutics (SLN) as of Q3 2025, down from 55 in Q2 2025.
  • Funds reported $96.4M of Silence Therapeutics stock for Q3 2025, down 11% quarter-over-quarter.
  • 6 funds opened new Silence Therapeutics positions in Q3 2025 and 7 closed out, a net change of -1 holder.
  • The largest Silence Therapeutics buyer in Q3 2025 was Millennium Management, an estimated $555K added.
  • The largest Silence Therapeutics seller in Q3 2025 was BlackRock, an estimated $591K sold.

Based on aggregated 13F filings for Q3 2025.