SLN

Silence Therapeutics
SLN

Overview Fund Activity

56 hedge funds and large institutions have $108M invested in Silence Therapeutics in 2025 Q2 according to their latest regulatory filings, with 9 funds opening new positions, 13 increasing their positions, 19 reducing their positions, and 13 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
56
Holders Change
-4
Holders Change %
-6.67%
% of All Funds
0.75%
Holding in Top 10
2
Holding in Top 10 Change
+2
Holding in Top 10 Change %
%
% of All Funds
0.03%
New
9
Increased
13
Reduced
19
Closed
13
Calls
$132K
Puts
$7K
Net Calls
+$125K
Net Calls Change
+$128K

Top Buyers

1
IC
Ikarian Capital
Texas
$1.4M
2
SL
Siren LLC
Connecticut
$16.9M
3
Jane Street
Jane Street
New York
$219K
4
Susquehanna International Group
Susquehanna International Group
Pennsylvania
$161K
5
WC
Wexford Capital
Florida
$157K

Top Sellers

1
Morgan Stanley
Morgan Stanley
New York
$7.03M
2
SVCM
Saturn V Capital Management
Texas
$201K
3
Millennium Management
Millennium Management
New York
$1.15M
4
PHP
Parkman Healthcare Partners
Connecticut
$0
5
FLSM
Frazier Life Sciences Management
California
$5.63M
Name Holding Trade Value Shares
Change 		Shares
Change %
TCM
1
TCG Crossover Management
California
$17.6M – – –
SL
2
Siren LLC
Connecticut
$16.9M +$705K +121,605 +4%
RG
3
Redmile Group
California
$12.6M -$291K -50,170 -2%
LOAMU
4
Lombard Odier Asset Management (USA)
New York
$7.81M – – –
Morgan Stanley
5
Morgan Stanley
New York
$7.03M -$4.57M -788,347 -39%
VC
6
Vivo Capital
California
$6.41M – – –
NCM
7
Nantahala Capital Management
Connecticut
$6.05M – – –
FLSM
8
Frazier Life Sciences Management
California
$5.63M -$1.04M -178,461 -16%
NI
9
Nextech Invest
Switzerland
$5.52M – – –
CF
10
Cantor Fitzgerald
New York
$4.58M +$88.1K +15,194 +2%
5VM
11
5AM Venture Management
California
$2.76M – – –
SG Americas Securities
12
SG Americas Securities
New York
$1.79M +$244 +42 +0%
BFM
13
Boothbay Fund Management
New York
$1.46M +$14K +2,409 +1%
IC
14
Ikarian Capital
Texas
$1.4M +$1.4M +873,568 New
UBS Group
15
UBS Group
Switzerland
$1.33M -$528K -91,005 -28%
Millennium Management
16
Millennium Management
New York
$1.15M -$1.15M -198,215 -50%
MCM
17
M28 Capital Management
Connecticut
$1.07M – – –
HSBC Holdings
18
HSBC Holdings
United Kingdom
$1.02M – – –
Marshall Wace
19
Marshall Wace
United Kingdom
$1.02M -$305K -52,556 -23%
BlackRock
20
BlackRock
New York
$976K -$70.8K -12,200 -7%
Bank of Montreal
21
Bank of Montreal
Ontario, Canada
$846K -$74.1K -12,781 -8%
WP
22
Woodline Partners
California
$362K -$418K -72,033 -54%
Two Sigma Investments
23
Two Sigma Investments
New York
$344K -$96.8K -16,696 -22%
Osaic Holdings
24
Osaic Holdings
Arizona
$281K -$211K -30,630 -43%
Two Sigma Advisers
25
Two Sigma Advisers
New York
$230K -$55.7K -9,600 -20%
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