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Rhythm Pharmaceuticals
RYTM

285 hedge funds and large institutions have $6.42B invested in Rhythm Pharmaceuticals in 2026 Q1 according to their latest regulatory filings, with 64 funds opening new positions, 101 increasing their positions, 89 reducing their positions, and 51 closing their positions.

New
Increased
Maintained
Reduced
Closed

776% more call options, than puts

Call options by funds: $16.4M | Put options by funds: $1.87M

25% more first-time investments, than exits

New positions opened: 64 | Existing positions closed: 51

13% more repeat investments, than reductions

Existing positions increased: 101 | Existing positions reduced: 89

2% more funds holding

Funds holding: 279 → 285 (+6)

0% more funds holding in top 10

Funds holding in top 10: 10 → 10 (0)

1.43% less ownership

Funds ownership: 109.17% → 107.74% (-1.4%)

18% less capital invested

Capital invested by funds: $7.8B → $6.42B (-$1.38B)

Holders
285
Holders Change
+6
Holders Change %
+2.15%
% of All Funds
3.51%
Holding in Top 10
10
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.12%
New
64
Increased
101
Reduced
89
Closed
51
Calls
$16.4M
Puts
$1.87M
Net Calls
+$14.5M
Net Calls Change
+$1.06M

Top Buyers

1
Citadel Advisors
Citadel Advisors
Florida
+$123M
2
Westfield Capital Management
Westfield Capital Management
Massachusetts
+$64.4M
3
PCH
Polar Capital Holdings
United Kingdom
+$41.8M
4
Point72 Asset Management
Point72 Asset Management
Connecticut
+$40.6M
5
Bank of America
Bank of America
North Carolina
+$39.3M

Top Sellers

1
NMC
NEA Management Company
Maryland
-$311M
2
Jennison Associates
Jennison Associates
New York
-$98.3M
3
DCM
Driehaus Capital Management
Illinois
-$82.5M
4
Federated Hermes
Federated Hermes
Pennsylvania
-$32.8M
5
Lord, Abbett & Co
Lord, Abbett & Co
New Jersey
-$26.3M
Name Holding Trade Value Shares
Change 		Change in
Stake
JF
301
Jump Financial
Illinois
– -$723K -6,759 Closed
LCM
302
Legato Capital Management
California
– -$613K -5,723 Closed
QC
303
Quantedge Capital
Singapore
– -$599K -5,600 Closed
VCM
304
Voleon Capital Management
California
– -$538K -5,025 Closed
PR
305
PSP Research
Pennsylvania
– -$507K -4,738 Closed
CM
306
Caption Management
Oklahoma
– -$494K -4,614 Closed
VAS
307
Vestmark Advisory Solutions
Massachusetts
– -$488K -4,560 Closed
Verition Fund Management
308
Verition Fund Management
Connecticut
– -$482K -4,504 Closed
Mackenzie Financial
309
Mackenzie Financial
Ontario, Canada
– -$469K -4,398 Closed
EF
310
Empowered Funds
Pennsylvania
– -$446K -4,164 Closed
OSAM
311
O'Shaughnessy Asset Management
Connecticut
– -$383K -3,580 Closed
TI
312
Tidal Investments
Wisconsin
– -$357K -3,336 Closed
KeyBank National Association
313
KeyBank National Association
Ohio
– -$350K -3,271 Closed
CCM
314
Cinctive Capital Management
New York
– -$345K -3,225 Closed
YMRC
315
Yorktown Management & Research Company
Virginia
– -$326K -3,050 Closed
Two Sigma Advisers
316
Two Sigma Advisers
New York
– -$310K -2,900 Closed
JGGDR
317
JGP Global Gestao de Recursos
Brazil
– -$307K -2,866 Closed
SOW
318
State of Wyoming
Wyoming
– -$261K -2,441 Closed
M&T Bank
319
M&T Bank
New York
– -$225K -2,101 Closed
CIM
320
Cambria Investment Management
California
– -$214K -1,997 Closed
Jane Street
321
Jane Street
New York
– -$191K -1,960 Closed
AB
322
Amalgamated Bank
New York
– -$178K -1,663 Closed
A
323
AlphaQuest
New York
– -$161K -1,508 Closed
PAP
324
Persistent Asset Partners
Hong Kong
– -$155K -1,446 Closed
CA
325
Clearstead Advisors
Ohio
– -$133K -1,246 Closed
10 11 12
13
14

RYTM Hedge Fund Activity: Q1 2026 in Review

285 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Rhythm Pharmaceuticals (RYTM) for Q1 2026, worth a combined $6.42B — down 18% from $7.8B a quarter earlier.

Buyers outnumbered sellers: 64 funds opened new RYTM positions and 51 closed out — a net gain of 13 holders — while 101 added to existing stakes and 89 trimmed.

The largest buyer was Citadel Advisors, adding an estimated $123M. The largest seller was NEA Management Company, exiting entirely with an estimated $311M sold.

  • 285 institutional investors held Rhythm Pharmaceuticals (RYTM) as of Q1 2026, up from 279 in Q4 2025.
  • Funds reported $6.42B of Rhythm Pharmaceuticals stock for Q1 2026, down 18% quarter-over-quarter.
  • 64 funds opened new Rhythm Pharmaceuticals positions in Q1 2026 and 51 closed out, a net change of +13 holders.
  • The largest Rhythm Pharmaceuticals buyer in Q1 2026 was Citadel Advisors, an estimated $123M added.
  • The largest Rhythm Pharmaceuticals seller in Q1 2026 was NEA Management Company, an estimated $311M sold.

Based on aggregated 13F filings for Q1 2026.