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QURE

Name Holding Trade Value Shares
Change 		Change in
Stake
Citadel Advisors
26
Citadel Advisors
Florida
$7.75M -$3.09M -229,455 -29%
Balyasny Asset Management
27
Balyasny Asset Management
Illinois
$7.49M +$6.89M +512,040 +2,054%
PFCS
28
Pale Fire Capital SE
Czech Republic
$7.39M +$907K +67,439 +15%
BNP Paribas Financial Markets
29
BNP Paribas Financial Markets
France
$7.02M +$299K +22,222 +5%
PFM
30
Privium Fund Management
Netherlands
$6.26M -$1.77M -131,653 -23%
PHP
31
Parkman Healthcare Partners
Connecticut
$6.18M +$3.22M +239,589 +118%
CCM
32
Catalio Capital Management
New York
$5.82M -$5.55M -412,882 -50%
Royal Bank of Canada
33
Royal Bank of Canada
Ontario, Canada
$5.46M +$4.6M +342,283 +694%
Goldman Sachs
34
Goldman Sachs
New York
$4.97M +$1.3M +96,826 +37%
Bank of New York Mellon
35
Bank of New York Mellon
New York
$4.86M +$4.69M +348,328 New
Charles Schwab
36
Charles Schwab
California
$4.08M +$174K +12,932 +5%
UBS Group
37
UBS Group
Switzerland
$3.68M +$495K +36,772 +16%
Marshall Wace
38
Marshall Wace
United Kingdom
$3.11M +$2.2M +163,749 +276%
APM
39
Avidity Partners Management
Texas
$2.89M -$1.74M -129,200 -38%
SCM
40
Silverarc Capital Management
Massachusetts
$2.82M -$11.2K -835 -0.4%
CM
41
Caption Management
Oklahoma
$2.47M +$2.11M +156,552 +769%
Squarepoint
42
Squarepoint
New York
$2.45M -$31.3K -2,330 -1%
WP
43
Woodline Partners
California
$2.45M – – –
MCM
44
Moore Capital Management
New York
$2.44M +$336K +25,000 +17%
PHS
45
PFM Health Sciences
California
$2.43M -$5.73M -425,636 -71%
Invesco
46
Invesco
Georgia
$2.33M -$4.28M -318,506 -66%
Hudson Bay Capital Management
47
Hudson Bay Capital Management
Connecticut
$2.07M -$47.3K -3,518 -2%
Bank of America
48
Bank of America
North Carolina
$1.98M -$3.22M -239,042 -63%
Jennison Associates
49
Jennison Associates
New York
$1.95M +$1.88M +140,060 New
AAA
50
Affinity Asset Advisors
New York
$1.88M -$3.56M -265,000 -66%
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