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uniQure
QURE

143 hedge funds and large institutions have $738M invested in uniQure in 2025 Q2 according to their latest regulatory filings, with 32 funds opening new positions, 43 increasing their positions, 48 reducing their positions, and 30 closing their positions.

New
Increased
Maintained
Reduced
Closed

325% more call options, than puts

Call options by funds: $81.3M | Put options by funds: $19.1M

38% more capital invested

Capital invested by funds: $533M → $738M (+$205M)

4.08% more ownership

Funds ownership: 92.61% → 96.69% (+4.1%)

1% more funds holding

Funds holding: 141 → 143 (+2)

7% more first-time investments, than exits

New positions opened: 32 | Existing positions closed: 30

10% less repeat investments, than reductions

Existing positions increased: 43 | Existing positions reduced: 48

33% less funds holding in top 10

Funds holding in top 10: 3 → 2 (-1)

Holders
143
Holders Change
+2
Holders Change %
+1.42%
% of All Funds
1.88%
Holding in Top 10
2
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-33.33%
% of All Funds
0.03%
New
32
Increased
43
Reduced
48
Closed
30
Calls
$81.3M
Puts
$19.1M
Net Calls
+$62.1M
Net Calls Change
+$44.9M

Top Buyers

Rank Fund Capital Flow
1
JFG
Jefferies Financial Group
New York
+$28.2M
2
JP Morgan Chase
JP Morgan Chase
New York
+$20.1M
3
ACA
Avoro Capital Advisors
New York
+$19.5M
4
SI
Sofinnova Investments
California
+$13.6M
5
RI
RTW Investments
New York
+$12M

Top Sellers

Rank Fund Capital Flow
1
VPC
Vestal Point Capital
New York
-$14.7M
2
NCM
Nantahala Capital Management
Connecticut
-$9.47M
3
Schroder Investment Management Group
Schroder Investment Management Group
United Kingdom
-$6.68M
4
PHS
PFM Health Sciences
California
-$5.73M
5
CCM
Catalio Capital Management
New York
-$5.55M
Name Holding Trade Value Shares
Change 		Change in
Stake
SSA
51
Schonfeld Strategic Advisors
New York
$1.88M +$1.25M +92,801 +220%
Millennium Management
52
Millennium Management
New York
$1.85M -$1.79M -133,002 -50%
Northern Trust
53
Northern Trust
Illinois
$1.75M +$360K +26,789 +27%
VC
54
Voss Capital
Texas
$1.74M +$1.68M +125,000 New
IC
55
Ikarian Capital
Texas
$1.67M +$1.61M +119,986 New
UBS AM
56
UBS AM
Illinois
$1.54M +$1.49M +110,576 New
Russell Investments Group
57
Russell Investments Group
United Kingdom
$1.48M -$2.65M -197,142 -65%
Point72 Asset Management
58
Point72 Asset Management
Connecticut
$1.48M -$325K -24,136 -19%
SC
59
Shay Capital
New York
$1.39M +$236K +17,534 +21%
BC
60
Birchview Capital
Vermont
$1.38M +$135K +10,000 +11%
SG Americas Securities
61
SG Americas Securities
New York
$1.32M +$1.27M +94,759 New
Verition Fund Management
62
Verition Fund Management
Connecticut
$1.29M -$53K -3,943 -4%
Barclays
63
Barclays
United Kingdom
$1.24M +$286K +21,270 +31%
Diamond Hill Capital Management
64
Diamond Hill Capital Management
Ohio
$1.15M – – –
Swiss National Bank
65
Swiss National Bank
Switzerland
$1.08M +$1.04M +77,500 New
SC
66
SummitTX Capital
Texas
$1.08M +$1.04M +77,495 New
MAM
67
Monaco Asset Management
Monaco
$976K -$67.3K -5,000 -7%
Rafferty Asset Management
68
Rafferty Asset Management
New York
$959K -$185K -13,782 -17%
VOYA Investment Management
69
VOYA Investment Management
Georgia
$938K +$245K +18,205 +37%
Stifel Financial
70
Stifel Financial
Missouri
$934K +$151K +11,213 +20%
Simplex Trading
71
Simplex Trading
Illinois
$895K +$225K +16,735 +35%
Group One Trading
72
Group One Trading
Illinois
$888K +$809K +60,136 +1,696%
UOC
73
UBS O'Connor
Illinois
$885K -$692K -51,414 -45%
YIH
74
Y-Intercept (HK)
Hong Kong
$872K +$841K +62,538 New
MMEA
75
Main Management ETF Advisors
California
$786K +$12.3K +912 +2%
1 2
3
4 5

QURE Hedge Fund Activity: Q2 2025 in Review

143 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in uniQure (QURE) for Q2 2025, worth a combined $738M — up 38% from $533M a quarter earlier.

Buyers outnumbered sellers: 32 funds opened new QURE positions and 30 closed out — a net gain of 2 holders — while 43 added to existing stakes and 48 trimmed.

The largest buyer was Jefferies Financial Group, opening a new position worth an estimated $28.2M. The largest seller was Vestal Point Capital, cutting an estimated $14.7M.

  • 143 institutional investors held uniQure (QURE) as of Q2 2025, up from 141 in Q1 2025.
  • Funds reported $738M of uniQure stock for Q2 2025, up 38% quarter-over-quarter.
  • 32 funds opened new uniQure positions in Q2 2025 and 30 closed out, a net change of +2 holders.
  • The largest uniQure buyer in Q2 2025 was Jefferies Financial Group, an estimated $28.2M added.
  • The largest uniQure seller in Q2 2025 was Vestal Point Capital, an estimated $14.7M sold.

Based on aggregated 13F filings for Q2 2025.