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Protagonist Therapeutics

317 hedge funds and large institutions have $8.3B invested in Protagonist Therapeutics in 2026 Q1 according to their latest regulatory filings, with 59 funds opening new positions, 110 increasing their positions, 102 reducing their positions, and 47 closing their positions.

New
Increased
Maintained
Reduced
Closed

225% more call options, than puts

Call options by funds: $36.2M | Put options by funds: $11.1M

34% more capital invested

Capital invested by funds: $6.18B → $8.3B (+$2.12B)

26% more first-time investments, than exits

New positions opened: 59 | Existing positions closed: 47

10.28% more ownership

Funds ownership: 113.13%123.41% (+10%)

1% more funds holding

Funds holding: 313317 (+4)

8% more repeat investments, than reductions

Existing positions increased: 110 | Existing positions reduced: 102

23% less funds holding in top 10

Funds holding in top 10: 1310 (-3)

Holders
317
Holders Change
+4
Holders Change %
+1.28%
% of All Funds
3.9%
Holding in Top 10
10
Holding in Top 10 Change
-3
Holding in Top 10 Change %
-23.08%
% of All Funds
0.12%
New
59
Increased
110
Reduced
102
Closed
47
Calls
$36.2M
Puts
$11.1M
Net Calls
+$25.1M
Net Calls Change
-$55.5M
Name Holding Trade Value Shares
Change
Change in
Stake
VAM
101
Vanguard Asset Management
$4.89M +$4.11M +46,386 New
O
102
OrbiMed
New York
$4.44M +$1.81M +20,400 +94%
Russell Investments Group
103
Russell Investments Group
United Kingdom
$4.26M +$3.07M +34,653 +606%
Thrivent Financial for Lutherans
104
Thrivent Financial for Lutherans
Minnesota
$4.13M -$102K -1,155 -3%
EC
105
Elmind Capital
New York
$4.01M
SOADOR
106
State of Alaska Department of Revenue
Alaska
$3.91M -$84.3K -952 -2%
BC
107
Birchview Capital
Vermont
$3.69M -$1.77M -20,000 -36%
HS
108
HighVista Strategies
Massachusetts
$3.57M -$3.51M -39,693 -54%
MIM
109
MetLife Investment Management
New Jersey
$3.35M -$56.8K -641 -2%
LP
110
LMR Partners
United Kingdom
$3.25M -$810K -9,150 -23%
State of Wisconsin Investment Board
111
State of Wisconsin Investment Board
Wisconsin
$3.24M -$356K -4,019 -12%
Mirae Asset Global ETFs Holdings
112
Mirae Asset Global ETFs Holdings
Hong Kong
$3.21M -$16.4K -185 -0.6%
Wells Fargo
113
Wells Fargo
California
$3.17M -$3.68M -41,573 -58%
Allspring Global Investments
114
Allspring Global Investments
North Carolina
$3.1M +$2.3M +25,931 +651%
IMRF
115
Illinois Municipal Retirement Fund
Illinois
$3.01M -$234K -2,648 -8%
Pathstone Holdings
116
Pathstone Holdings
New Jersey
$2.98M +$1.05M +11,811 +72%
EI
117
EAM Investors
California
$2.94M -$4.48M -50,584 -64%
GIM
118
Granahan Investment Management
Massachusetts
$2.89M +$2.43M +27,391 New
Connor, Clark & Lunn Investment Management (CC&L)
119
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$2.87M +$1.24M +13,990 +105%
TRSOTSOK
120
Teachers Retirement System of the State of Kentucky
Kentucky
$2.8M
LSERS
121
Louisiana State Employees Retirement System
Louisiana
$2.75M -$70.8K -800 -3%
VGA
122
Vanguard Global Advisers
Pennsylvania
$2.6M +$2.18M +24,665 New
Polen Capital Management
123
Polen Capital Management
Florida
$2.57M +$353K +3,988 +20%
ETC
124
Exchange Traded Concepts
Oklahoma
$2.51M -$998K -11,266 -32%
Calamos Advisors
125
Calamos Advisors
Illinois
$2.47M +$2.08M +23,473 New