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Protagonist Therapeutics

317 hedge funds and large institutions have $8.3B invested in Protagonist Therapeutics in 2026 Q1 according to their latest regulatory filings, with 59 funds opening new positions, 110 increasing their positions, 102 reducing their positions, and 47 closing their positions.

New
Increased
Maintained
Reduced
Closed

225% more call options, than puts

Call options by funds: $36.2M | Put options by funds: $11.1M

34% more capital invested

Capital invested by funds: $6.18B → $8.3B (+$2.12B)

26% more first-time investments, than exits

New positions opened: 59 | Existing positions closed: 47

10.28% more ownership

Funds ownership: 113.13%123.41% (+10%)

1% more funds holding

Funds holding: 313317 (+4)

8% more repeat investments, than reductions

Existing positions increased: 110 | Existing positions reduced: 102

23% less funds holding in top 10

Funds holding in top 10: 1310 (-3)

Holders
317
Holders Change
+4
Holders Change %
+1.28%
% of All Funds
3.9%
Holding in Top 10
10
Holding in Top 10 Change
-3
Holding in Top 10 Change %
-23.08%
% of All Funds
0.12%
New
59
Increased
110
Reduced
102
Closed
47
Calls
$36.2M
Puts
$11.1M
Net Calls
+$25.1M
Net Calls Change
-$55.5M
Name Holding Trade Value Shares
Change
Change in
Stake
ClearBridge Investments
26
ClearBridge Investments
New York
$65.5M +$11.7M +131,978 +27%
Alyeska Investment Group
27
Alyeska Investment Group
Illinois
$62.5M +$34.9M +393,674 +197%
Northern Trust
28
Northern Trust
Illinois
$62M +$1.14M +12,850 +2%
Pictet Asset Management
29
Pictet Asset Management
Switzerland
$61.2M +$4.56M +51,452 +10%
NNPTE
30
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne
Poland
$60.3M
Charles Schwab
31
Charles Schwab
California
$58.3M -$337K -3,806 -0.7%
American Century Companies
32
American Century Companies
Missouri
$56.6M +$168K +1,897 +0.4%
Dimensional Fund Advisors
33
Dimensional Fund Advisors
Texas
$53.5M +$8.3M +93,688 +23%
VOYA Investment Management
34
VOYA Investment Management
Georgia
$47.9M +$7.81M +88,218 +24%
RCMNY
35
Rubric Capital Management (New York)
New York
$45.1M +$37.9M +427,998 New
VFT
36
Vanguard Fiduciary Trust
Pennsylvania
$43.5M +$36.5M +412,730 New
Principal Financial Group
37
Principal Financial Group
Iowa
$38.8M +$1.76M +19,890 +6%
6CM
38
683 Capital Management
New York
$37.4M -$2.27M -25,669 -7%
Bank of New York Mellon
39
Bank of New York Mellon
New York
$36M -$790K -8,923 -3%
VPC
40
Vestal Point Capital
New York
$34.4M +$28.9M +326,159 New
BNP Paribas Asset Management
41
BNP Paribas Asset Management
France
$32.3M -$2.19M -24,767 -7%
Adage Capital Partners
42
Adage Capital Partners
Massachusetts
$29.8M +$4.39M +49,600 +21%
SAM
43
SEB Asset Management
$24.5M +$20.6M +232,416 New
NCM
44
NEXTBio Capital Management
California
$24.2M
SBH
45
Segall Bryant & Hamill
Illinois
$22.4M +$7.41M +83,654 +65%
Public Sector Pension Investment Board (PSP Investments)
46
Public Sector Pension Investment Board (PSP Investments)
Quebec, Canada
$22.2M +$607K +6,854 +3%
Holocene Advisors
47
Holocene Advisors
New York
$22.1M -$9.12K -103 -0%
BNP Paribas Financial Markets
48
BNP Paribas Financial Markets
France
$20.5M +$8.57M +96,766 +99%
TD Asset Management
49
TD Asset Management
Ontario, Canada
$19.4M +$2.21M +24,970 +16%
EHI
50
Eagle Health Investments
Connecticut
$18.9M +$10.8M +122,022 +213%