PTGX icon

Protagonist Therapeutics

313 hedge funds and large institutions have $6.18B invested in Protagonist Therapeutics in 2025 Q4 according to their latest regulatory filings, with 82 funds opening new positions, 97 increasing their positions, 103 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding in top 10

Funds holding in top 10:

14% more funds holding

Funds holding: 274313 (+39)

0.49% less ownership

Funds ownership: 113.62%113.13% (-0.49%)

6% less repeat investments, than reductions

Existing positions increased: 97 | Existing positions reduced: 103

Holders
313
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
13
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$85.2M
Puts
$4.57M
Net Calls
Net Calls Change

Top Buyers

1 +$127M
2 +$103M
3 +$94.7M
4
Citadel Advisors
Citadel Advisors
Florida
+$72.7M
5
UBS Group
UBS Group
Switzerland
+$71.5M

Top Sellers

1 -$170M
2 -$114M
3 -$66.8M
4
RI
RTW Investments
New York
-$57.1M
5
CC
Commodore Capital
New York
-$47.1M
Name Holding Trade Value Shares
Change
Change in
Stake
AAP
301
Arax Advisory Partners
Colorado
$874
TC
302
Trust Company
Kansas
$611
FHA
303
Flagship Harbor Advisors
Massachusetts
$524
GWM
304
Gilpin Wealth Management
Colorado
$437
AWM
305
Abound Wealth Management
Tennessee
$350
KG
306
Kilter Group
New York
$350
DF
307
DecisionPoint Financial
Arizona
$350
TCM
308
TD Capital Management
Tennessee
$349
RFP
309
Root Financial Partners
California
$262
HI
310
Harbour Investments
Wisconsin
$175
HFS
311
Hughes Financial Services
Virginia
$175
KFAS
312
Keating Financial Advisory Services
Kansas
$175
BI
313
BVF Inc
California
DTC
314
Deep Track Capital
Connecticut
LCM
315
Lynx1 Capital Management
Puerto Rico
MP
316
Mangrove Partners
Connecticut
Focus Partners Wealth
317
Focus Partners Wealth
Massachusetts
Toronto Dominion Bank
318
Toronto Dominion Bank
Ontario, Canada
LGM
319
Logos Global Management
California
ECM
320
ExodusPoint Capital Management
New York
SSA
321
Schonfeld Strategic Advisors
New York
Assenagon Asset Management
322
Assenagon Asset Management
Luxembourg
AA
323
ALPS Advisors
Colorado
SCM
324
Superstring Capital Management
New York
Capital Fund Management (CFM)
325
Capital Fund Management (CFM)
France