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Protagonist Therapeutics

313 hedge funds and large institutions have $6.18B invested in Protagonist Therapeutics in 2025 Q4 according to their latest regulatory filings, with 82 funds opening new positions, 97 increasing their positions, 103 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding in top 10

Funds holding in top 10:

14% more funds holding

Funds holding: 274313 (+39)

0.49% less ownership

Funds ownership: 113.62%113.13% (-0.49%)

6% less repeat investments, than reductions

Existing positions increased: 97 | Existing positions reduced: 103

Holders
313
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
13
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$85.2M
Puts
$4.57M
Net Calls
Net Calls Change

Top Buyers

1 +$127M
2 +$103M
3 +$94.7M
4
Citadel Advisors
Citadel Advisors
Florida
+$72.7M
5
UBS Group
UBS Group
Switzerland
+$71.5M

Top Sellers

1 -$170M
2 -$114M
3 -$66.8M
4
RI
RTW Investments
New York
-$57.1M
5
CC
Commodore Capital
New York
-$47.1M
Name Holding Trade Value Shares
Change
Change in
Stake
SAG
276
SageView Advisory Group
California
$9.26K
DB
277
Danske Bank
Denmark
$8.73K
MCM
278
MAI Capital Management
Ohio
$8.47K
WA
279
WPG Advisers
Maryland
$8.38K
RIL
280
Rothschild Investment LLC
Illinois
$7.51K
PFBT
281
Parkside Financial Bank & Trust
Missouri
$7.34K
BIA
282
Bell Investment Advisors
California
$7.08K
BBHC
283
Brown Brothers Harriman & Co
New York
$7.08K
AGWCA
284
Annis Gardner Whiting Capital Advisors
Florida
$6.64K
SS
285
SBI Securities
Japan
$6.11K
SG
286
Sankala Group
Colorado
$5.53K
Jones Financial Companies
287
Jones Financial Companies
Missouri
$4.02K
TM
288
Torren Management
California
$3.41K
HNB
289
Huntington National Bank
Ohio
$3.06K
FMII
290
Farmers & Merchants Investments Inc
Nebraska
$3.06K
WWM
291
Wolff Wiese Magana
California
$3.06K
MAM
292
Marquette Asset Management
Minnesota
$2.45K
VCM
293
Versant Capital Management
Arizona
$2.36K
PMAM
294
Picton Mahoney Asset Management
Ontario, Canada
$2.18K
EW
295
Elyxium Wealth
California
$1.92K
PWA
296
Physician Wealth Advisors
Utah
$1.83K
OP
297
ORG Partners
Indiana
$1.66K
TCM
298
Triumph Capital Management
Colorado
$1.57K
CIBC Private Wealth Group
299
CIBC Private Wealth Group
Georgia
$1.14K
AW
300
Ankerstar Wealth
Texas
$1.05K