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Protagonist Therapeutics

313 hedge funds and large institutions have $6.18B invested in Protagonist Therapeutics in 2025 Q4 according to their latest regulatory filings, with 82 funds opening new positions, 97 increasing their positions, 103 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding in top 10

Funds holding in top 10:

14% more funds holding

Funds holding: 274313 (+39)

0.49% less ownership

Funds ownership: 113.62%113.13% (-0.49%)

6% less repeat investments, than reductions

Existing positions increased: 97 | Existing positions reduced: 103

Holders
313
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
13
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$85.2M
Puts
$4.57M
Net Calls
Net Calls Change

Top Buyers

1 +$127M
2 +$103M
3 +$94.7M
4
Citadel Advisors
Citadel Advisors
Florida
+$72.7M
5
UBS Group
UBS Group
Switzerland
+$71.5M

Top Sellers

1 -$170M
2 -$114M
3 -$66.8M
4
RI
RTW Investments
New York
-$57.1M
5
CC
Commodore Capital
New York
-$47.1M
Name Holding Trade Value Shares
Change
Change in
Stake
GFM
251
GF Fund Management
China
$107K
TC
252
Truvestments Capital
Florida
$101K
CH
253
Canton Hathaway
Rhode Island
$87.3K
HFS
254
Hantz Financial Services
Michigan
$83K
CWMS
255
CFG Wealth Management Services
Indiana
$52.6K
Carson Wealth (CWM LLC)
256
Carson Wealth (CWM LLC)
Nebraska
$49K
EWA
257
EverSource Wealth Advisors
Alabama
$48.8K
SSG
258
Summit Securities Group
New York
$43.7K
SL
259
Salomon & Ludwin
Virginia
$36.7K
SCM
260
Sterling Capital Management
North Carolina
$33K
UB
261
UMB Bank
Missouri
$29.1K
Fifth Third Bancorp
262
Fifth Third Bancorp
Ohio
$28.6K
GWM
263
Greenline Wealth Management
Florida
$26.5K
FFA
264
Farther Finance Advisors
California
$25.9K
AssetMark Inc
265
AssetMark Inc
California
$24.9K
SIS
266
Sound Income Strategies
Florida
$23.3K
CA
267
Clearstead Advisors
Ohio
$19.4K
Daiwa Securities Group
268
Daiwa Securities Group
Japan
$17K
KAS
269
Kemnay Advisory Services
New York
$15.8K
LFG
270
Larson Financial Group
Missouri
$14.9K
S
271
SignatureFD
Georgia
$14.2K
MTC
272
Matrix Trust Company
Colorado
$12K
MPWT
273
MassMutual Private Wealth & Trust
Connecticut
$10.4K
BFS
274
Bare Financial Services
Pennsylvania
$9.61K
PA
275
Parallel Advisors
California
$9.52K