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Protagonist Therapeutics

312 hedge funds and large institutions have $6.18B invested in Protagonist Therapeutics in 2025 Q4 according to their latest regulatory filings, with 81 funds opening new positions, 97 increasing their positions, 103 reducing their positions, and 39 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more capital invested

Capital invested by funds: $ → $

more funds holding in top 10

Funds holding in top 10:

14% more funds holding

Funds holding: 274312 (+38)

0.49% less ownership

Funds ownership: 113.62%113.13% (-0.49%)

6% less repeat investments, than reductions

Existing positions increased: 97 | Existing positions reduced: 103

Holders
312
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
13
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$85.2M
Puts
$4.57M
Net Calls
Net Calls Change

Top Buyers

1 +$127M
2 +$103M
3 +$94.7M
4
Citadel Advisors
Citadel Advisors
Florida
+$72.7M
5
UBS Group
UBS Group
Switzerland
+$71.5M

Top Sellers

1 -$170M
2 -$114M
3 -$66.8M
4
RI
RTW Investments
New York
-$57.1M
5
CC
Commodore Capital
New York
-$47.1M
Name Holding Trade Value Shares
Change
Change in
Stake
GFM
251
GF Fund Management
China
$107K
TC
252
Truvestments Capital
Florida
$101K
CH
253
Canton Hathaway
Rhode Island
$87.3K
HFS
254
Hantz Financial Services
Michigan
$83K
Carson Wealth (CWM LLC)
255
Carson Wealth (CWM LLC)
Nebraska
$49K
EWA
256
EverSource Wealth Advisors
Alabama
$48.8K
SSG
257
Summit Securities Group
New York
$43.7K
SL
258
Salomon & Ludwin
Virginia
$36.7K
SCM
259
Sterling Capital Management
North Carolina
$33K
UB
260
UMB Bank
Missouri
$29.1K
Fifth Third Bancorp
261
Fifth Third Bancorp
Ohio
$28.6K
GWM
262
Greenline Wealth Management
Florida
$26.5K
FFA
263
Farther Finance Advisors
California
$25.9K
AssetMark Inc
264
AssetMark Inc
California
$24.9K
SIS
265
Sound Income Strategies
Florida
$23.3K
CA
266
Clearstead Advisors
Ohio
$19.4K
Daiwa Securities Group
267
Daiwa Securities Group
Japan
$17K
KAS
268
Kemnay Advisory Services
New York
$15.8K
LFG
269
Larson Financial Group
Missouri
$14.9K
S
270
SignatureFD
Georgia
$14.2K
MTC
271
Matrix Trust Company
Colorado
$12K
MPWT
272
MassMutual Private Wealth & Trust
Connecticut
$10.4K
BFS
273
Bare Financial Services
Pennsylvania
$9.61K
PA
274
Parallel Advisors
California
$9.52K
SAG
275
SageView Advisory Group
California
$9.26K