PRME icon

Prime Medicine

182 hedge funds and large institutions have $337M invested in Prime Medicine in 2025 Q4 according to their latest regulatory filings, with 43 funds opening new positions, 67 increasing their positions, 40 reducing their positions, and 26 closing their positions.

New
Increased
Maintained
Reduced
Closed

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less call options, than puts

Call options by funds: $ | Put options by funds: $

14.87% less ownership

Funds ownership: 68.62%53.75% (-15%)

34% less capital invested

Capital invested by funds: $512M → $337M (-$175M)

50% less funds holding in top 10

Funds holding in top 10: 21 (-1)

Holders
182
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
1
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$3.21M
Puts
$3.5M
Net Calls
Net Calls Change

Top Buyers

1 +$16.9M
2 +$13.7M
3 +$11.6M
4
UBS Group
UBS Group
Switzerland
+$9.5M
5
Vanguard Group
Vanguard Group
Pennsylvania
+$6.88M

Top Sellers

1 -$16.6M
2 -$15.6M
3 -$14.3M
4
EC
EcoR1 Capital
California
-$8.55M
5
Millennium Management
Millennium Management
New York
-$6.08M
Name Holding Trade Value Shares
Change
Change in
Stake
S
151
SignatureFD
Georgia
$17.4K
Royal Bank of Canada
152
Royal Bank of Canada
Ontario, Canada
$17K
Nisa Investment Advisors
153
Nisa Investment Advisors
Missouri
$15.8K
GFM
154
GF Fund Management
China
$12.3K
FCG
155
Financial Connections Group
California
$12K
AB
156
Amalgamated Bank
New York
$11K
AF
157
Allworth Financial
California
$10.8K
MIM
158
MTM Investment Management
South Carolina
$10.7K
EWA
159
EverSource Wealth Advisors
Alabama
$6.11K
SA
160
Scarborough Advisors
Maryland
$4.36K
CC
161
Corsicana & Co
Texas
$3.47K
NA
162
NewEdge Advisors
Louisiana
$3.47K
LSA
163
Leonteq Securities AG
Switzerland
$3.17K
TRCT
164
Tower Research Capital (TRC)
New York
$2.8K
FG
165
Fairman Group
Pennsylvania
$1.74K
RIL
166
Rothschild Investment LLC
Illinois
$1.2K
PNC Financial Services Group
167
PNC Financial Services Group
Pennsylvania
$1.11K
SS
168
SBI Securities
Japan
$1.05K
FFO
169
Fortitude Family Office
Arizona
$1.03K
Daiwa Securities Group
170
Daiwa Securities Group
Japan
$1K
PFBT
171
Parkside Financial Bank & Trust
Missouri
$989
MCM
172
MAI Capital Management
Ohio
$951
CIBC Private Wealth Group
173
CIBC Private Wealth Group
Georgia
$926
EP
174
Essential Partners
California
$767
Optiver Holding
175
Optiver Holding
Netherlands
$555