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Prime Medicine

182 hedge funds and large institutions have $337M invested in Prime Medicine in 2025 Q4 according to their latest regulatory filings, with 43 funds opening new positions, 67 increasing their positions, 40 reducing their positions, and 26 closing their positions.

New
Increased
Maintained
Reduced
Closed

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less call options, than puts

Call options by funds: $ | Put options by funds: $

14.87% less ownership

Funds ownership: 68.62%53.75% (-15%)

34% less capital invested

Capital invested by funds: $512M → $337M (-$175M)

50% less funds holding in top 10

Funds holding in top 10: 21 (-1)

Holders
182
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
1
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$3.21M
Puts
$3.5M
Net Calls
Net Calls Change

Top Buyers

1 +$16.9M
2 +$13.7M
3 +$11.6M
4
UBS Group
UBS Group
Switzerland
+$9.5M
5
Vanguard Group
Vanguard Group
Pennsylvania
+$6.88M

Top Sellers

1 -$16.6M
2 -$15.6M
3 -$14.3M
4
EC
EcoR1 Capital
California
-$8.55M
5
Millennium Management
Millennium Management
New York
-$6.08M
Name Holding Trade Value Shares
Change
Change in
Stake
SA
126
Sanctuary Advisors
Indiana
$50.9K
PCIA
127
Prime Capital Investment Advisors
Kansas
$48.8K
SIAP
128
Sterling Investment Advisors (Pennsylvania)
Pennsylvania
$46.5K
JEST
129
JTC Employer Solutions Trustee
Jersey
$46K
OC
130
Oppenheimer & Co
New York
$43.1K
Teacher Retirement System of Texas
131
Teacher Retirement System of Texas
Texas
$42.5K
FDCDDQ
132
Federation des caisses Desjardins du Quebec
Quebec, Canada
$41.6K
IAS
133
Integrity Advisory Solutions
Texas
$40.6K
CFO
134
Callan Family Office
Pennsylvania
$39.2K
Neuberger Berman Group
135
Neuberger Berman Group
New York
$37.9K
Lazard Asset Management
136
Lazard Asset Management
New York
$37.6K
Victory Capital Management
137
Victory Capital Management
Texas
$37.5K
RIA
138
Rhodes Investment Advisors
Texas
$37.3K
PCM
139
Prelude Capital Management
New York
$35.4K
FFM
140
Forum Financial Management
Illinois
$34.7K
GEA
141
Glen Eagle Advisors
New Jersey
$34.7K
BNP Paribas Financial Markets
142
BNP Paribas Financial Markets
France
$34.1K
Zurich Cantonal Bank
143
Zurich Cantonal Bank
Switzerland
$30.6K
Mirae Asset Global Investments
144
Mirae Asset Global Investments
South Korea
$30.4K
New York State Common Retirement Fund
145
New York State Common Retirement Fund
New York
$29.3K
Osaic Holdings
146
Osaic Holdings
Arizona
$29.2K
Russell Investments Group
147
Russell Investments Group
United Kingdom
$23.7K
AIP
148
Ameritas Investment Partners
Nebraska
$20.5K
SCM
149
Sterling Capital Management
North Carolina
$19.9K
NS
150
NBC Securities
Alabama
$17.4K