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Prime Medicine
PRME

Overview Fund Activity

123 hedge funds and large institutions have $120M invested in Prime Medicine in 2025 Q1 according to their latest regulatory filings, with 21 funds opening new positions, 41 increasing their positions, 35 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
123
Holders Change
-7
Holders Change %
-5.38%
% of All Funds
1.67%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
21
Increased
41
Reduced
35
Closed
27
Calls
$120K
Puts
$237K
Net Calls
-$117K
Net Calls Change
+$193K

Top Buyers

1
Renaissance Technologies
Renaissance Technologies
New York
+$891K
2
AQR Capital Management
AQR Capital Management
Connecticut
+$453K
3
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
+$329K
4
GCP
GSA Capital Partners
United Kingdom
+$275K
5
Susquehanna International Group
Susquehanna International Group
Pennsylvania
+$210K

Top Sellers

1
AIM
ARK Investment Management
Florida
-$4.09M
2
WHG
Westwood Holdings Group
Texas
-$2.58M
3
Walleye Capital
Walleye Capital
New York
-$1.18M
4
Bank of America
Bank of America
North Carolina
-$632K
5
BlackRock
BlackRock
New York
-$435K
Name Holding Trade Value Shares
Change 		Shares
Change %
Jane Street
126
Jane Street
New York
– -$297K -101,758 Closed
AC
127
Aristides Capital
Kentucky
– -$206K -70,500 Closed
Point72 Asset Management
128
Point72 Asset Management
Connecticut
– -$200K -68,528 Closed
SC
129
Sculptor Capital
New York
– -$148K -50,700 Closed
PEAK6
130
PEAK6
Illinois
– -$87.6K -30,013 Closed
Creative Planning
131
Creative Planning
Kansas
– -$80.7K -27,623 Closed
MIM
132
MetLife Investment Management
New Jersey
– -$73.1K -25,031 Closed
VEA
133
Virtus ETF Advisers
New York
– -$69K -23,618 Closed
HF
134
HRT Financial
New York
– -$63K -21,695 Closed
SPA
135
Sherbrooke Park Advisers
New York
– -$59.7K -20,441 Closed
IPW
136
Impact Partnership Wealth
Georgia
– -$50.4K -17,274 Closed
Balyasny Asset Management
137
Balyasny Asset Management
Illinois
– -$47.7K -16,342 Closed
AC
138
AXQ Capital
New Jersey
– -$44.9K -15,363 Closed
XT
139
XTX Topco
Cayman Islands
– -$42.2K -14,466 Closed
OC
140
Oppenheimer & Co
New York
– -$35.4K -12,106 Closed
RS
141
R Squared
Hong Kong
– -$6.51K -2,230 Closed
National Bank of Canada
142
National Bank of Canada
Quebec, Canada
– -$1.17K -400 Closed
PD
143
Point72 (DIFC)
United Arab Emirates
– -$902 -309 Closed
US Bancorp
144
US Bancorp
Minnesota
– -$590 -202 Closed
AF
145
Allworth Financial
California
– -$449 -141 Closed
MPWT
146
MassMutual Private Wealth & Trust
Connecticut
– -$304 -104 Closed
Federated Hermes
147
Federated Hermes
Pennsylvania
– -$18 -6 Closed
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