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Prime Medicine

180 hedge funds and large institutions have $336M invested in Prime Medicine in 2025 Q4 according to their latest regulatory filings, with 42 funds opening new positions, 65 increasing their positions, 40 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

less call options, than puts

Call options by funds: $ | Put options by funds: $

14.91% less ownership

Funds ownership: 68.63%53.72% (-15%)

34% less capital invested

Capital invested by funds: $512M → $336M (-$175M)

50% less funds holding in top 10

Funds holding in top 10: 21 (-1)

Holders
180
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
1
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$3.21M
Puts
$3.5M
Net Calls
Net Calls Change

Top Buyers

1 +$16.9M
2 +$13.7M
3 +$11.6M
4
UBS Group
UBS Group
Switzerland
+$9.5M
5
Vanguard Group
Vanguard Group
Pennsylvania
+$6.88M

Top Sellers

1 -$16.6M
2 -$15.6M
3 -$14.3M
4
EC
EcoR1 Capital
California
-$8.55M
5
Millennium Management
Millennium Management
New York
-$6.08M
Name Holding Trade Value Shares
Change
Change in
Stake
CAG
101
Crestwood Advisors Group
Massachusetts
$111K
Manulife (Manufacturers Life Insurance)
102
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$110K
SG Americas Securities
103
SG Americas Securities
New York
$107K
CUAMC
104
China Universal Asset Management Company
China
$102K
Wealth Enhancement Advisory Services
105
Wealth Enhancement Advisory Services
Minnesota
$96.6K
Raymond James Financial
106
Raymond James Financial
Florida
$93.8K
TCA
107
Transcend Capital Advisors
New Jersey
$92K
ProShare Advisors
108
ProShare Advisors
Maryland
$90.8K
Carson Wealth (CWM LLC)
109
Carson Wealth (CWM LLC)
Nebraska
$88K
APG
110
Abacus Planning Group
South Carolina
$87.4K
Nomura Holdings
111
Nomura Holdings
Japan
$86K
ASRS
112
Arizona State Retirement System
Arizona
$83.6K
VPIM
113
Vanguard Personalized Indexing Management
California
$82.1K
Voloridge Investment Management
114
Voloridge Investment Management
Florida
$80.2K
TDC
115
Thompson Davis & Co
Virginia
$78.9K
SRL
116
Scientech Research LLC
New Jersey
$77.7K
PFSRSONJ
117
Police & Firemen's Retirement System of New Jersey
New Jersey
$73.4K
SWM
118
Shelton Wealth Management
Texas
$69.6K
KK
119
KLP Kapitalforvaltning
Norway
$64.2K
Creative Planning
120
Creative Planning
Kansas
$62.1K
VOYA Investment Management
121
VOYA Investment Management
Georgia
$60.7K
CGL
122
Clarius Group LLC
Washington
$55.8K
KWM
123
Kingsview Wealth Management
Oregon
$52K
LCS
124
Levin Capital Strategies
New York
$52K
MAM
125
Martingale Asset Management
Massachusetts
$51.4K