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Prime Medicine
PRME

183 hedge funds and large institutions have $337M invested in Prime Medicine in 2025 Q4 according to their latest regulatory filings, with 44 funds opening new positions, 67 increasing their positions, 40 reducing their positions, and 26 closing their positions.

New
Increased
Maintained
Reduced
Closed

69% more first-time investments, than exits

New positions opened: 44 | Existing positions closed: 26

68% more repeat investments, than reductions

Existing positions increased: 67 | Existing positions reduced: 40

10% more funds holding

Funds holding: 167 → 183 (+16)

8% less call options, than puts

Call options by funds: $3.21M | Put options by funds: $3.5M

14.87% less ownership

Funds ownership: 68.62% → 53.75% (-15%)

34% less capital invested

Capital invested by funds: $512M → $337M (-$175M)

50% less funds holding in top 10

Funds holding in top 10: 2 → 1 (-1)

Holders
183
Holders Change
+16
Holders Change %
+9.58%
% of All Funds
2.23%
Holding in Top 10
1
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-50%
% of All Funds
0.01%
New
44
Increased
67
Reduced
40
Closed
26
Calls
$3.21M
Puts
$3.5M
Net Calls
-$295K
Net Calls Change
-$2.87M

Top Buyers

Rank Fund Capital Flow
1
State Street
State Street
Massachusetts
+$16.9M
2
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$13.7M
3
BlackRock
BlackRock
New York
+$11.6M
4
UBS Group
UBS Group
Switzerland
+$9.5M
5
Vanguard Group
Vanguard Group
Pennsylvania
+$6.88M

Top Sellers

Rank Fund Capital Flow
1
RCM
RA Capital Management
Massachusetts
-$16.6M
2
FCM
Farallon Capital Management
California
-$15.6M
3
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
-$14.3M
4
EC
EcoR1 Capital
California
-$8.55M
5
Millennium Management
Millennium Management
New York
-$6.08M
Name Holding Trade Value Shares
Change 		Change in
Stake
HF
26
HRT Financial
New York
$2.27M +$1.93M +433,887 +196%
Bank of America
27
Bank of America
North Carolina
$2.25M +$2.39M +537,170 +485%
Point72 Asset Management
28
Point72 Asset Management
Connecticut
$1.91M +$2.45M +551,030 New
MCM
29
Moore Capital Management
New York
$1.74M – – –
JP Morgan Chase
30
JP Morgan Chase
New York
$1.51M +$1.75M +392,321 +904%
AQR Capital Management
31
AQR Capital Management
Connecticut
$1.44M +$7.16K +1,610 +0.4%
HighTower Advisors
32
HighTower Advisors
Illinois
$1.39M +$295K +66,355 +20%
Two Sigma Advisers
33
Two Sigma Advisers
New York
$1.33M +$1.71M +383,500 New
Barclays
34
Barclays
United Kingdom
$1.26M +$1.1M +247,926 +214%
BG
35
Bollard Group
Massachusetts
$1.25M – – –
Wells Fargo
36
Wells Fargo
California
$1.02M +$434K +97,482 +49%
Verition Fund Management
37
Verition Fund Management
Connecticut
$1.01M +$1.29M +290,983 New
N
38
Nuveen
North Carolina
$873K +$115K +25,793 +11%
Wellington Management Group
39
Wellington Management Group
Massachusetts
$861K +$191K +42,902 +21%
Bank of New York Mellon
40
Bank of New York Mellon
New York
$856K +$218K +49,041 +25%
CCC
41
Chelsea Counsel Company
California
$788K +$83.6K +18,790 +9%
DFCM
42
Dark Forest Capital Management
Puerto Rico
$784K +$1M +225,859 New
Squarepoint
43
Squarepoint
New York
$757K +$794K +178,441 +451%
GAA
44
Green Alpha Advisors
Colorado
$662K +$2.36K +530 +0.3%
Rafferty Asset Management
45
Rafferty Asset Management
New York
$651K +$835K +187,711 New
IEFM
46
IQ EQ Fund Management
Ireland
$619K +$257K +57,746 +48%
JF
47
Jump Financial
Illinois
$597K +$765K +171,931 New
Swiss National Bank
48
Swiss National Bank
Switzerland
$590K +$757K +170,100 New
Deutsche Bank
49
Deutsche Bank
Germany
$513K +$67.5K +15,174 +11%
BCM
50
Bridgeway Capital Management
Texas
$468K -$133K -30,000 -18%
1
2
3 4 5

PRME Hedge Fund Activity: Q4 2025 in Review

183 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Prime Medicine (PRME) for Q4 2025, worth a combined $337M — down 34% from $512M a quarter earlier.

Buyers outnumbered sellers: 44 funds opened new PRME positions and 26 closed out — a net gain of 18 holders — while 67 added to existing stakes and 40 trimmed.

The largest buyer was State Street, adding an estimated $16.9M. The largest seller was RA Capital Management, exiting entirely with an estimated $16.6M sold.

  • 183 institutional investors held Prime Medicine (PRME) as of Q4 2025, up from 167 in Q3 2025.
  • Funds reported $337M of Prime Medicine stock for Q4 2025, down 34% quarter-over-quarter.
  • 44 funds opened new Prime Medicine positions in Q4 2025 and 26 closed out, a net change of +18 holders.
  • The largest Prime Medicine buyer in Q4 2025 was State Street, an estimated $16.9M added.
  • The largest Prime Medicine seller in Q4 2025 was RA Capital Management, an estimated $16.6M sold.

Based on aggregated 13F filings for Q4 2025.