We are live on ! Find out more
PLRX icon

Pliant Therapeutics
PLRX

140 hedge funds and large institutions have $78.5M invested in Pliant Therapeutics in 2025 Q1 according to their latest regulatory filings, with 32 funds opening new positions, 42 increasing their positions, 39 reducing their positions, and 50 closing their positions.

New
Increased
Maintained
Reduced
Closed

2,040% more call options, than puts

Call options by funds: $214K | Put options by funds: $10K

8% more repeat investments, than reductions

Existing positions increased: 42 | Existing positions reduced: 39

11.88% less ownership

Funds ownership: 106.42% → 94.53% (-12%)

13% less funds holding

Funds holding: 160 → 140 (-20)

36% less first-time investments, than exits

New positions opened: 32 | Existing positions closed: 50

83% less funds holding in top 10

Funds holding in top 10: 6 → 1 (-5)

91% less capital invested

Capital invested by funds: $853M → $78.5M (-$774M)

Holders
140
Holders Change
-20
Holders Change %
-12.5%
% of All Funds
1.88%
Holding in Top 10
1
Holding in Top 10 Change
-5
Holding in Top 10 Change %
-83.33%
% of All Funds
0.01%
New
32
Increased
42
Reduced
39
Closed
50
Calls
$214K
Puts
$10K
Net Calls
+$204K
Net Calls Change
+$9.61M

Top Buyers

Rank Fund Capital Flow
1
TCM
Tang Capital Management
California
+$36.4M
2
CAM
Cormorant Asset Management
Massachusetts
+$18.2M
3
WP
Woodline Partners
California
+$14.5M
4
Morgan Stanley
Morgan Stanley
New York
+$13.8M
5
UBS Group
UBS Group
Switzerland
+$12.2M

Top Sellers

Rank Fund Capital Flow
1
PBA
Paradigm Biocapital Advisors
New York
-$42.1M
2
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$27.6M
3
PCH
Polar Capital Holdings
United Kingdom
-$26.5M
4
Fidelity Investments
Fidelity Investments
Massachusetts
-$23.4M
5
FLAM
First Light Asset Management
Minnesota
-$22.1M
Name Holding Trade Value Shares
Change 		Change in
Stake
XT
26
XTX Topco
Cayman Islands
$630K +$2.83M +466,842 New
AI
27
Allostery Investments
Connecticut
$596K +$2.68M +441,686 New
CWM
28
Congress Wealth Management
Massachusetts
$570K +$2.56M +422,311 New
Charles Schwab
29
Charles Schwab
California
$526K -$425K -70,035 -15%
Royal Bank of Canada
30
Royal Bank of Canada
Ontario, Canada
$491K +$1.52M +250,185 +222%
Two Sigma Advisers
31
Two Sigma Advisers
New York
$462K +$1.25M +206,500 +152%
PM
32
Prosight Management
Texas
$451K +$2.03M +334,263 New
GCM
33
Graham Capital Management
Connecticut
$450K +$2.02M +333,421 New
ACH
34
ArrowMark Colorado Holdings
Colorado
$380K – – –
Two Sigma Investments
35
Two Sigma Investments
New York
$372K +$1.08M +178,209 +184%
Verition Fund Management
36
Verition Fund Management
Connecticut
$355K +$1.59M +262,698 New
SEI Investments
37
SEI Investments
Pennsylvania
$333K +$1.5M +247,008 New
Marshall Wace
38
Marshall Wace
United Kingdom
$282K +$939K +154,652 +287%
BNP Paribas Financial Markets
39
BNP Paribas Financial Markets
France
$249K +$1.07M +176,881 +2,355%
Bank of New York Mellon
40
Bank of New York Mellon
New York
$234K -$68.9K -11,357 -6%
HWM
41
HighMark Wealth Management
Minnesota
$213K +$501K +82,500 +110%
UBS AM
42
UBS AM
Illinois
$209K +$93.1K +15,332 +11%
Squarepoint
43
Squarepoint
New York
$207K +$791K +130,263 +556%
RHJA
44
Rice Hall James & Associates
California
$207K -$45.7K -7,528 -5%
Renaissance Technologies
45
Renaissance Technologies
New York
$206K +$757K +124,700 +449%
Jane Street
46
Jane Street
New York
$185K -$275K -45,299 -25%
American Century Companies
47
American Century Companies
Missouri
$149K +$56.1K +9,244 +9%
HS
48
HighVista Strategies
Massachusetts
$148K +$667K +109,938 New
HWAM
49
Hennion & Walsh Asset Management
New Jersey
$141K -$25.4K -4,178 -4%
BDFN
50
Bond & Devick Financial Network
Minnesota
$135K – – –
1
2
3 4 5

PLRX Hedge Fund Activity: Q1 2025 in Review

140 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Pliant Therapeutics (PLRX) for Q1 2025, worth a combined $78.5M — down 91% from $853M a quarter earlier.

Sellers outnumbered buyers: 50 funds closed out of PLRX and 32 opened new positions — a net loss of 18 holders — while 39 trimmed existing stakes and 42 added.

The largest buyer was Tang Capital Management, opening a new position worth an estimated $36.4M. The largest seller was Paradigm Biocapital Advisors, exiting entirely with an estimated $42.1M sold.

  • 140 institutional investors held Pliant Therapeutics (PLRX) as of Q1 2025, down from 160 in Q4 2024.
  • Funds reported $78.5M of Pliant Therapeutics stock for Q1 2025, down 91% quarter-over-quarter.
  • 32 funds opened new Pliant Therapeutics positions in Q1 2025 and 50 closed out, a net change of -18 holders.
  • The largest Pliant Therapeutics buyer in Q1 2025 was Tang Capital Management, an estimated $36.4M added.
  • The largest Pliant Therapeutics seller in Q1 2025 was Paradigm Biocapital Advisors, an estimated $42.1M sold.

Based on aggregated 13F filings for Q1 2025.