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Opko Health
OPK

255 hedge funds and large institutions have $401M invested in Opko Health in 2025 Q1 according to their latest regulatory filings, with 43 funds opening new positions, 76 increasing their positions, 58 reducing their positions, and 23 closing their positions.

New
Increased
Maintained
Reduced
Closed

490% more call options, than puts

Call options by funds: $5.13M | Put options by funds: $870K

87% more first-time investments, than exits

New positions opened: 43 | Existing positions closed: 23

38% more capital invested

Capital invested by funds: $290M → $401M (+$111M)

31% more repeat investments, than reductions

Existing positions increased: 76 | Existing positions reduced: 58

9% more funds holding

Funds holding: 235 → 255 (+20)

7.1% more ownership

Funds ownership: 28.95% → 36.05% (+7.1%)

Holders
255
Holders Change
+20
Holders Change %
+8.51%
% of All Funds
3.42%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
43
Increased
76
Reduced
58
Closed
23
Calls
$5.13M
Puts
$870K
Net Calls
+$4.26M
Net Calls Change
+$12.2M

Top Buyers

Rank Fund Capital Flow
1
SC
Sculptor Capital
New York
+$20.9M
2
WAM
Weiss Asset Management
Massachusetts
+$18.4M
3
DM
Deerfield Management
New York
+$11.4M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$7.79M
5
Marshall Wace
Marshall Wace
United Kingdom
+$6.55M

Top Sellers

Rank Fund Capital Flow
1
UBS Group
UBS Group
Switzerland
-$3.96M
2
Jane Street
Jane Street
New York
-$3.72M
3
Citadel Advisors
Citadel Advisors
Florida
-$2.23M
4
IECM
Intrinsic Edge Capital Management
Illinois
-$1.62M
5
State Street
State Street
Massachusetts
-$1.54M
Name Holding Trade Value Shares
Change 		Change in
Stake
SPC
176
Sigma Planning Corp
Michigan
$29.8K – – –
Mariner
177
Mariner
Kansas
$29K +$28.8K +17,463 New
SRC
178
Shufro Rose & Co
New York
$28.2K – – –
Stifel Financial
179
Stifel Financial
Missouri
$28K +$109 +66 +0.4%
CG
180
Caprock Group
Idaho
$27.8K +$27.6K +16,770 New
WP
181
Westmount Partners
California
$27.5K – – –
CWM
182
C2C Wealth Management
Arizona
$27.2K +$2.29K +1,390 +9%
CC
183
Commons Capital
Massachusetts
$27.1K – – –
OTL
184
Oak Thistle LLC
New York
$26K +$25.8K +15,636 New
FAM
185
Formidable Asset Management
Ohio
$25K – – –
CFO
186
Colony Family Offices
North Carolina
$24.4K – – –
SA
187
Sanctuary Advisors
Indiana
$23.6K +$23.4K +14,191 New
AHL
188
Abel Hall LLC
Louisiana
$23.5K +$6.66K +4,044 +40%
BAM
189
Blueshift Asset Management
New Jersey
$23K +$22.8K +13,870 New
SSA
190
Schonfeld Strategic Advisors
New York
$21.7K +$21.6K +13,100 New
Canada Pension Plan Investment Board
191
Canada Pension Plan Investment Board
Ontario, Canada
$21.4K +$21.2K +12,900 New
RS
192
R Squared
Hong Kong
$20.4K +$20.2K +12,290 New
FFA
193
Farther Finance Advisors
California
$20.3K +$609 +370 +3%
Jones Financial Companies
194
Jones Financial Companies
Missouri
$19.8K +$4.94K +3,000 +35%
FC
195
Farringdon Capital
United Kingdom
$19.6K +$19.5K +11,834 New
TIA
196
Traphagen Investment Advisors
New Jersey
$19.4K – – –
Focus Partners Wealth
197
Focus Partners Wealth
Massachusetts
$19.1K +$19K +11,524 New
HSA
198
HBK Sorce Advisory
Pennsylvania
$18.9K – – –
SCA
199
Stillwater Capital Advisors
Pennsylvania
$18.9K – – –
GAM
200
Gotham Asset Management
New York
$18.4K +$18.2K +11,056 New
6 7
8
9 10

OPK Hedge Fund Activity: Q1 2025 in Review

255 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Opko Health (OPK) for Q1 2025, worth a combined $401M — up 38% from $290M a quarter earlier.

Buyers outnumbered sellers: 43 funds opened new OPK positions and 23 closed out — a net gain of 20 holders — while 76 added to existing stakes and 58 trimmed.

The largest buyer was Sculptor Capital, opening a new position worth an estimated $20.9M. The largest seller was UBS Group, cutting an estimated $3.96M.

  • 255 institutional investors held Opko Health (OPK) as of Q1 2025, up from 235 in Q4 2024.
  • Funds reported $401M of Opko Health stock for Q1 2025, up 38% quarter-over-quarter.
  • 43 funds opened new Opko Health positions in Q1 2025 and 23 closed out, a net change of +20 holders.
  • The largest Opko Health buyer in Q1 2025 was Sculptor Capital, an estimated $20.9M added.
  • The largest Opko Health seller in Q1 2025 was UBS Group, an estimated $3.96M sold.

Based on aggregated 13F filings for Q1 2025.