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Opko Health
OPK

255 hedge funds and large institutions have $401M invested in Opko Health in 2025 Q1 according to their latest regulatory filings, with 43 funds opening new positions, 76 increasing their positions, 58 reducing their positions, and 23 closing their positions.

New
Increased
Maintained
Reduced
Closed

490% more call options, than puts

Call options by funds: $5.13M | Put options by funds: $870K

87% more first-time investments, than exits

New positions opened: 43 | Existing positions closed: 23

38% more capital invested

Capital invested by funds: $290M → $401M (+$111M)

31% more repeat investments, than reductions

Existing positions increased: 76 | Existing positions reduced: 58

9% more funds holding

Funds holding: 235 → 255 (+20)

7.1% more ownership

Funds ownership: 28.95% → 36.05% (+7.1%)

Holders
255
Holders Change
+20
Holders Change %
+8.51%
% of All Funds
3.42%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
43
Increased
76
Reduced
58
Closed
23
Calls
$5.13M
Puts
$870K
Net Calls
+$4.26M
Net Calls Change
+$12.2M

Top Buyers

Rank Fund Capital Flow
1
SC
Sculptor Capital
New York
+$20.9M
2
WAM
Weiss Asset Management
Massachusetts
+$18.4M
3
DM
Deerfield Management
New York
+$11.4M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$7.79M
5
Marshall Wace
Marshall Wace
United Kingdom
+$6.55M

Top Sellers

Rank Fund Capital Flow
1
UBS Group
UBS Group
Switzerland
-$3.96M
2
Jane Street
Jane Street
New York
-$3.72M
3
Citadel Advisors
Citadel Advisors
Florida
-$2.23M
4
IECM
Intrinsic Edge Capital Management
Illinois
-$1.62M
5
State Street
State Street
Massachusetts
-$1.54M
Name Holding Trade Value Shares
Change 		Change in
Stake
GF
76
Gabelli Funds
New York
$282K – – –
MIM
77
MetLife Investment Management
New Jersey
$273K -$62.5K -37,935 -19%
CF
78
Corebridge Financial
Texas
$259K -$9.37K -5,687 -4%
TA
79
Teton Advisors
New York
$240K -$9.06K -5,500 -4%
N
80
Numerai
California
$221K -$10.8K -6,568 -5%
Manulife (Manufacturers Life Insurance)
81
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$207K -$9.96K -6,050 -5%
CSS
82
Cubist Systematic Strategies
Connecticut
$198K +$188K +114,396 +2,370%
HWP
83
Highline Wealth Partners
California
$194K – – –
VanEck Associates
84
VanEck Associates
New York
$188K +$11.1K +6,722 +6%
Comerica Bank
85
Comerica Bank
Texas
$186K +$9.27K +5,631 +5%
PF
86
Phoenix Financial
Israel
$171K – – –
Cambridge Investment Research Advisors
87
Cambridge Investment Research Advisors
Iowa
$171K – – –
CAG
88
Csenge Advisory Group
Florida
$166K – – –
ICM
89
Intrepid Capital Management
Florida
$166K – – –
ASRS
90
Arizona State Retirement System
Arizona
$162K -$4.95K -3,005 -3%
Ameriprise
91
Ameriprise
Minnesota
$156K -$494 -300 -0.3%
American Century Companies
92
American Century Companies
Missouri
$154K +$153K +92,785 New
HCM
93
Hollencrest Capital Management
California
$149K – – –
Raymond James Financial
94
Raymond James Financial
Florida
$142K -$108K -65,300 -43%
Balyasny Asset Management
95
Balyasny Asset Management
Illinois
$140K +$121K +73,432 +682%
Teacher Retirement System of Texas
96
Teacher Retirement System of Texas
Texas
$139K +$138K +83,766 New
3F
97
360 Financial
Minnesota
$132K -$2.47K -1,500 -2%
CAU
98
Caxton Associates (UK)
$130K +$129K +78,128 New
QC
99
Quadrature Capital
United Kingdom
$129K +$128K +77,658 New
PFSRSONJ
100
Police & Firemen's Retirement System of New Jersey
New Jersey
$129K – – –
2 3
4
5 6

OPK Hedge Fund Activity: Q1 2025 in Review

255 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Opko Health (OPK) for Q1 2025, worth a combined $401M — up 38% from $290M a quarter earlier.

Buyers outnumbered sellers: 43 funds opened new OPK positions and 23 closed out — a net gain of 20 holders — while 76 added to existing stakes and 58 trimmed.

The largest buyer was Sculptor Capital, opening a new position worth an estimated $20.9M. The largest seller was UBS Group, cutting an estimated $3.96M.

  • 255 institutional investors held Opko Health (OPK) as of Q1 2025, up from 235 in Q4 2024.
  • Funds reported $401M of Opko Health stock for Q1 2025, up 38% quarter-over-quarter.
  • 43 funds opened new Opko Health positions in Q1 2025 and 23 closed out, a net change of +20 holders.
  • The largest Opko Health buyer in Q1 2025 was Sculptor Capital, an estimated $20.9M added.
  • The largest Opko Health seller in Q1 2025 was UBS Group, an estimated $3.96M sold.

Based on aggregated 13F filings for Q1 2025.