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Opko Health
OPK

255 hedge funds and large institutions have $401M invested in Opko Health in 2025 Q1 according to their latest regulatory filings, with 43 funds opening new positions, 76 increasing their positions, 58 reducing their positions, and 23 closing their positions.

New
Increased
Maintained
Reduced
Closed

490% more call options, than puts

Call options by funds: $5.13M | Put options by funds: $870K

87% more first-time investments, than exits

New positions opened: 43 | Existing positions closed: 23

38% more capital invested

Capital invested by funds: $290M → $401M (+$111M)

31% more repeat investments, than reductions

Existing positions increased: 76 | Existing positions reduced: 58

9% more funds holding

Funds holding: 235 → 255 (+20)

7.1% more ownership

Funds ownership: 28.95% → 36.05% (+7.1%)

Holders
255
Holders Change
+20
Holders Change %
+8.51%
% of All Funds
3.42%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
43
Increased
76
Reduced
58
Closed
23
Calls
$5.13M
Puts
$870K
Net Calls
+$4.26M
Net Calls Change
+$12.2M

Top Buyers

Rank Fund Capital Flow
1
SC
Sculptor Capital
New York
+$20.9M
2
WAM
Weiss Asset Management
Massachusetts
+$18.4M
3
DM
Deerfield Management
New York
+$11.4M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$7.79M
5
Marshall Wace
Marshall Wace
United Kingdom
+$6.55M

Top Sellers

Rank Fund Capital Flow
1
UBS Group
UBS Group
Switzerland
-$3.96M
2
Jane Street
Jane Street
New York
-$3.72M
3
Citadel Advisors
Citadel Advisors
Florida
-$2.23M
4
IECM
Intrinsic Edge Capital Management
Illinois
-$1.62M
5
State Street
State Street
Massachusetts
-$1.54M
Name Holding Trade Value Shares
Change 		Change in
Stake
DWM
251
Darwin Wealth Management
Florida
$7 – – –
LI
252
LRI Investments
Florida
$2 +$2 +1 New
IECM
253
Intrinsic Edge Capital Management
Illinois
– -$1.62M -1,100,000 Closed
SM
254
Skaana Management
New York
– -$704K -478,614 Closed
EP
255
Essential Planning
New Hampshire
– -$506K -331,175 Closed
Renaissance Technologies
256
Renaissance Technologies
New York
– -$215K -145,977 Closed
WCM
257
Whitefort Capital Management
New York
– -$198K -134,490 Closed
Wolverine Trading
258
Wolverine Trading
Illinois
– -$144K -97,722 Closed
YIH
259
Y-Intercept (HK)
Hong Kong
– -$102K -69,591 Closed
BHCM
260
Brevan Howard Capital Management
Jersey
– -$97.4K -66,282 Closed
CFM
261
Catalyst Funds Management
Australia
– -$90.6K -61,600 Closed
ZIM
262
Zacks Investment Management
Illinois
– -$49K -33,300 Closed
EWM
263
Empirical Wealth Management
Washington
– -$29.4K -20,000 Closed
GIP
264
Granite Investment Partners
California
– -$21.1K -14,356 Closed
GS
265
GTS Securities
New York
– -$19K -12,944 Closed
MCCA
266
Mill Creek Capital Advisors
Pennsylvania
– -$18.2K -12,383 Closed
Ohio Public Employees Retirement System (OPERS)
267
Ohio Public Employees Retirement System (OPERS)
Ohio
– -$16.3K -11,055 Closed
Pathstone Holdings
268
Pathstone Holdings
New Jersey
– -$16.2K -10,541 Closed
ML
269
McAdam LLC
Pennsylvania
– -$14.8K -10,054 Closed
GM
270
GeoWealth Management
Illinois
– -$1.79K -1,215 Closed
S
271
SignatureFD
Georgia
– -$1.47K -1,000 Closed
Fifth Third Bancorp
272
Fifth Third Bancorp
Ohio
– -$809 -550 Closed
SMAM
273
Sugar Maple Asset Management
Wisconsin
– -$515 -350 Closed
NFSG
274
Newbridge Financial Services Group
Florida
– -$147 -100 Closed
C
275
Covestor
United Kingdom
– -$30 -18 -17%
8 9 10
11
12

OPK Hedge Fund Activity: Q1 2025 in Review

255 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Opko Health (OPK) for Q1 2025, worth a combined $401M — up 38% from $290M a quarter earlier.

Buyers outnumbered sellers: 43 funds opened new OPK positions and 23 closed out — a net gain of 20 holders — while 76 added to existing stakes and 58 trimmed.

The largest buyer was Sculptor Capital, opening a new position worth an estimated $20.9M. The largest seller was UBS Group, cutting an estimated $3.96M.

  • 255 institutional investors held Opko Health (OPK) as of Q1 2025, up from 235 in Q4 2024.
  • Funds reported $401M of Opko Health stock for Q1 2025, up 38% quarter-over-quarter.
  • 43 funds opened new Opko Health positions in Q1 2025 and 23 closed out, a net change of +20 holders.
  • The largest Opko Health buyer in Q1 2025 was Sculptor Capital, an estimated $20.9M added.
  • The largest Opko Health seller in Q1 2025 was UBS Group, an estimated $3.96M sold.

Based on aggregated 13F filings for Q1 2025.