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Opko Health
OPK

255 hedge funds and large institutions have $401M invested in Opko Health in 2025 Q1 according to their latest regulatory filings, with 43 funds opening new positions, 76 increasing their positions, 58 reducing their positions, and 23 closing their positions.

New
Increased
Maintained
Reduced
Closed

490% more call options, than puts

Call options by funds: $5.13M | Put options by funds: $870K

87% more first-time investments, than exits

New positions opened: 43 | Existing positions closed: 23

38% more capital invested

Capital invested by funds: $290M → $401M (+$111M)

31% more repeat investments, than reductions

Existing positions increased: 76 | Existing positions reduced: 58

9% more funds holding

Funds holding: 235 → 255 (+20)

7.1% more ownership

Funds ownership: 28.95% → 36.05% (+7.1%)

Holders
255
Holders Change
+20
Holders Change %
+8.51%
% of All Funds
3.42%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
43
Increased
76
Reduced
58
Closed
23
Calls
$5.13M
Puts
$870K
Net Calls
+$4.26M
Net Calls Change
+$12.2M

Top Buyers

Rank Fund Capital Flow
1
SC
Sculptor Capital
New York
+$20.9M
2
WAM
Weiss Asset Management
Massachusetts
+$18.4M
3
DM
Deerfield Management
New York
+$11.4M
4
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$7.79M
5
Marshall Wace
Marshall Wace
United Kingdom
+$6.55M

Top Sellers

Rank Fund Capital Flow
1
UBS Group
UBS Group
Switzerland
-$3.96M
2
Jane Street
Jane Street
New York
-$3.72M
3
Citadel Advisors
Citadel Advisors
Florida
-$2.23M
4
IECM
Intrinsic Edge Capital Management
Illinois
-$1.62M
5
State Street
State Street
Massachusetts
-$1.54M
Name Holding Trade Value Shares
Change 		Change in
Stake
CIAM
226
Caitong International Asset Management
Hong Kong
$3.02K +$1.29K +784 +76%
CA
227
CoreCap Advisors
Michigan
$2.88K +$221 +134 +8%
AF
228
Allworth Financial
California
$2.37K – – –
US Bancorp
229
US Bancorp
Minnesota
$2.37K +$1.36K +828 +138%
WGS
230
Washington Growth Strategies
District of Columbia
$2.25K +$3 +2 New
PP
231
PFS Partners
New Jersey
$1.83K – – –
MCM
232
MAI Capital Management
Ohio
$1.66K – – –
SL
233
Salomon & Ludwin
Virginia
$1.65K – – –
T
234
Transce3nd
Texas
$1.49K -$916 -556 -38%
TWD
235
True Wealth Design
Ohio
$1.29K +$1.27K +772 +9,650%
CIAS
236
CBIZ Investment Advisory Services
Ohio
$1.16K – – –
Russell Investments Group
237
Russell Investments Group
United Kingdom
$1.03K -$362 -220 -26%
SAM
238
Smartleaf Asset Management
Massachusetts
$805 -$5.48K -3,329 -88%
PAI
239
Pittenger & Anderson Inc
Nebraska
$415 – – –
GBT
240
Grove Bank & Trust
Florida
$415 +$412 +250 New
Northwestern Mutual Wealth Management
241
Northwestern Mutual Wealth Management
Wisconsin
$377 -$374 -227 -50%
RIL
242
Rothschild Investment LLC
Illinois
$332 – – –
MWA
243
Medallion Wealth Advisors
Connecticut
$332 +$329 +200 New
HIA
244
Harbor Investment Advisory
Maryland
$299 +$296 +180 New
IA
245
IFP Advisors
Florida
$171 – – –
SIC
246
Salem Investment Counselors
North Carolina
$166 – – –
TC
247
Truvestments Capital
Florida
$166 +$165 +100 New
SS
248
SBI Securities
Japan
$154 +$3 +2 +2%
LFG
249
Larson Financial Group
Missouri
$66 – – –
NA
250
NewEdge Advisors
Louisiana
$32 – – –
8 9
10
11 12

OPK Hedge Fund Activity: Q1 2025 in Review

255 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Opko Health (OPK) for Q1 2025, worth a combined $401M — up 38% from $290M a quarter earlier.

Buyers outnumbered sellers: 43 funds opened new OPK positions and 23 closed out — a net gain of 20 holders — while 76 added to existing stakes and 58 trimmed.

The largest buyer was Sculptor Capital, opening a new position worth an estimated $20.9M. The largest seller was UBS Group, cutting an estimated $3.96M.

  • 255 institutional investors held Opko Health (OPK) as of Q1 2025, up from 235 in Q4 2024.
  • Funds reported $401M of Opko Health stock for Q1 2025, up 38% quarter-over-quarter.
  • 43 funds opened new Opko Health positions in Q1 2025 and 23 closed out, a net change of +20 holders.
  • The largest Opko Health buyer in Q1 2025 was Sculptor Capital, an estimated $20.9M added.
  • The largest Opko Health seller in Q1 2025 was UBS Group, an estimated $3.96M sold.

Based on aggregated 13F filings for Q1 2025.