Omeros
OMER
161 hedge funds and large institutions have $326M invested in Omeros in 2026 Q1 according to their latest regulatory filings, with 37 funds opening new positions, 61 increasing their positions, 41 reducing their positions, and 21 closing their positions.
76% more first-time investments, than exits
New positions opened: 37 | Existing positions closed: 21
49% more repeat investments, than reductions
Existing positions increased: 61 | Existing positions reduced: 41
8% more funds holding
Funds holding: 149 → 161 (+12)
9% more call options, than puts
Call options by funds: $11.3M | Put options by funds: $10.4M
4.37% less ownership
Funds ownership: 47.83% → 43.46% (-4.4%)
44% less capital invested
Capital invested by funds: $582M → $326M (-$256M)
50% less funds holding in top 10
Funds holding in top 10: 2 → 1 (-1)
Top Buyers
| 1 |
State Street
Boston,
Massachusetts
|
+$4.08M |
| 2 |
BlackRock
New York
|
+$2.91M |
| 3 |
PM
Prosight Management
Dallas,
Texas
|
+$2.06M |
| 4 |
CCM
Clutterbuck Capital Management
Cleveland,
Ohio
|
+$1.77M |
| 5 |
PAMP
Polar Asset Management Partners
Toronto,
Ontario, Canada
|
+$1.55M |
Top Sellers
| 1 |
D.E. Shaw & Co
New York
|
-$8.06M |
| 2 |
Nomura Holdings
Tokyo,
Japan
|
-$7.27M |
| 3 |
Corient Private Wealth
Miami,
Florida
|
-$6.76M |
| 4 |
Royal Bank of Canada
Toronto,
Ontario, Canada
|
-$5.86M |
| 5 |
Jane Street
New York
|
-$3.75M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
|
AHL
176
Abel Hall LLC
Baton Rouge,
Louisiana
| – | -$176K | -10,240 | Closed |
|
|
AB
177
Amalgamated Bank
New York
| – | -$36K | -2,069 | Closed |
|
|
SOW
178
State of Wyoming
Cheyenne,
Wyoming
| – | -$24.6K | -1,433 | Closed |
|
179
Daiwa Securities Group
Tokyo,
Japan
| – | -$3K | -191 | Closed |
|
|
SA
180
SRH Advisors
Salina,
Kansas
| – | -$859 | -50 | Closed |
|
|
PFBT
181
Parkside Financial Bank & Trust
Saint Louis,
Missouri
| – | -$687 | -40 | Closed |
|
|
C
182
Covestor
London,
United Kingdom
| – | +$118 | +10 | New |
|
OMER Hedge Fund Activity: Q1 2026 in Review
161 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Omeros (OMER) for Q1 2026, worth a combined $326M — down 44% from $582M a quarter earlier.
Buyers outnumbered sellers: 37 funds opened new OMER positions and 21 closed out — a net gain of 16 holders — while 61 added to existing stakes and 41 trimmed.
The largest buyer was State Street, adding an estimated $4.08M. The largest seller was D.E. Shaw & Co, cutting an estimated $8.06M.
- 161 institutional investors held Omeros (OMER) as of Q1 2026, up from 149 in Q4 2025.
- Funds reported $326M of Omeros stock for Q1 2026, down 44% quarter-over-quarter.
- 37 funds opened new Omeros positions in Q1 2026 and 21 closed out, a net change of +16 holders.
- The largest Omeros buyer in Q1 2026 was State Street, an estimated $4.08M added.
- The largest Omeros seller in Q1 2026 was D.E. Shaw & Co, an estimated $8.06M sold.
Based on aggregated 13F filings for Q1 2026.