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Omeros
OMER

133 hedge funds and large institutions have $135M invested in Omeros in 2025 Q3 according to their latest regulatory filings, with 15 funds opening new positions, 58 increasing their positions, 30 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

93% more repeat investments, than reductions

Existing positions increased: 58 | Existing positions reduced: 30

67% more first-time investments, than exits

New positions opened: 15 | Existing positions closed: 9

54% more capital invested

Capital invested by funds: $87.3M → $135M (+$47.4M)

5% more funds holding

Funds holding: 127 → 133 (+6)

5% less call options, than puts

Call options by funds: $10.4M | Put options by funds: $10.9M

1.41% less ownership

Funds ownership: 49.68% → 48.27% (-1.4%)

Holders
133
Holders Change
+6
Holders Change %
+4.72%
% of All Funds
1.75%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
15
Increased
58
Reduced
30
Closed
9
Calls
$10.4M
Puts
$10.9M
Net Calls
-$517K
Net Calls Change
+$1.24M

Top Buyers

Rank Fund Capital Flow
1
PAMP
Polar Asset Management Partners
Ontario, Canada
+$5.95M
2
Morgan Stanley
Morgan Stanley
New York
+$2.52M
3
BlackRock
BlackRock
New York
+$1.59M
4
JP Morgan Chase
JP Morgan Chase
New York
+$1.52M
5
Stifel Financial
Stifel Financial
Missouri
+$1.15M

Top Sellers

Rank Fund Capital Flow
1
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$2.55M
2
DIG
DeepCurrents Investment Group
New York
-$1.62M
3
Marshall Wace
Marshall Wace
United Kingdom
-$1.1M
4
UBS Group
UBS Group
Switzerland
-$632K
5
GCM
Graham Capital Management
Connecticut
-$262K
Name Holding Trade Value Shares
Change 		Change in
Stake
BlackRock
1
BlackRock
New York
$18.3M +$1.59M +401,183 +10%
ISL
2
Ingalls & Snyder LLC
New York
$16.8M +$491K +123,685 +3%
Vanguard Group
3
Vanguard Group
Pennsylvania
$13.7M +$251K +63,381 +2%
Morgan Stanley
4
Morgan Stanley
New York
$8.16M +$2.52M +634,175 +47%
Stifel Financial
5
Stifel Financial
Missouri
$7.43M +$1.15M +289,385 +19%
Geode Capital Management
6
Geode Capital Management
Massachusetts
$6.3M +$657K +165,500 +12%
PAMP
7
Polar Asset Management Partners
Ontario, Canada
$6.14M +$5.95M +1,498,586 New
State Street
8
State Street
Massachusetts
$5.08M +$157K +39,602 +3%
D.E. Shaw & Co
9
D.E. Shaw & Co
New York
$4.12M -$2.55M -642,191 -39%
Two Sigma Investments
10
Two Sigma Investments
New York
$3.83M +$1.04M +263,095 +39%
UBS Group
11
UBS Group
Switzerland
$2.91M -$632K -159,411 -18%
Corient Private Wealth
12
Corient Private Wealth
Florida
$2.5M +$310K +78,148 +15%
Two Sigma Advisers
13
Two Sigma Advisers
New York
$2.37M +$617K +155,400 +37%
Bank of Montreal
14
Bank of Montreal
Ontario, Canada
$2.31M -$31.7K -8,000 -1%
Charles Schwab
15
Charles Schwab
California
$2.27M +$293K +73,788 +15%
Royal Bank of Canada
16
Royal Bank of Canada
Ontario, Canada
$2.23M +$157K +39,608 +8%
Northern Trust
17
Northern Trust
Illinois
$2.2M +$202K +50,927 +11%
Marshall Wace
18
Marshall Wace
United Kingdom
$1.9M -$1.1M -277,198 -37%
JP Morgan Chase
19
JP Morgan Chase
New York
$1.71M +$1.52M +384,168 +1,201%
Millennium Management
20
Millennium Management
New York
$1.65M +$525K +132,393 +49%
Citadel Advisors
21
Citadel Advisors
Florida
$1.61M +$934K +235,518 +149%
Renaissance Technologies
22
Renaissance Technologies
New York
$1.41M -$152K -38,200 -10%
Goldman Sachs
23
Goldman Sachs
New York
$1.38M +$326K +82,123 +32%
Jane Street
24
Jane Street
New York
$1.15M +$776K +195,705 +229%
Bank of America
25
Bank of America
North Carolina
$1.13M +$97K +24,459 +10%
1
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OMER Hedge Fund Activity: Q3 2025 in Review

133 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Omeros (OMER) for Q3 2025, worth a combined $135M — up 54% from $87.3M a quarter earlier.

Buyers outnumbered sellers: 15 funds opened new OMER positions and 9 closed out — a net gain of 6 holders — while 58 added to existing stakes and 30 trimmed.

The largest buyer was Polar Asset Management Partners, opening a new position worth an estimated $5.95M. The largest seller was D.E. Shaw & Co, cutting an estimated $2.55M.

  • 133 institutional investors held Omeros (OMER) as of Q3 2025, up from 127 in Q2 2025.
  • Funds reported $135M of Omeros stock for Q3 2025, up 54% quarter-over-quarter.
  • 15 funds opened new Omeros positions in Q3 2025 and 9 closed out, a net change of +6 holders.
  • The largest Omeros buyer in Q3 2025 was Polar Asset Management Partners, an estimated $5.95M added.
  • The largest Omeros seller in Q3 2025 was D.E. Shaw & Co, an estimated $2.55M sold.

Based on aggregated 13F filings for Q3 2025.