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Omeros
OMER

149 hedge funds and large institutions have $582M invested in Omeros in 2025 Q4 according to their latest regulatory filings, with 33 funds opening new positions, 60 increasing their positions, 34 reducing their positions, and 15 closing their positions.

New
Increased
Maintained
Reduced
Closed

332% more capital invested

Capital invested by funds: $135M → $582M (+$447M)

120% more first-time investments, than exits

New positions opened: 33 | Existing positions closed: 15

76% more repeat investments, than reductions

Existing positions increased: 60 | Existing positions reduced: 34

20% more call options, than puts

Call options by funds: $77.2M | Put options by funds: $64.5M

12% more funds holding

Funds holding: 133 → 149 (+16)

0.44% less ownership

Funds ownership: 48.27% → 47.83% (-0.44%)

Holders
149
Holders Change
+16
Holders Change %
+12.03%
% of All Funds
1.81%
Holding in Top 10
2
Holding in Top 10 Change
+2
Holding in Top 10 Change %
% of All Funds
0.02%
New
33
Increased
60
Reduced
34
Closed
15
Calls
$77.2M
Puts
$64.5M
Net Calls
+$12.6M
Net Calls Change
+$13.1M

Top Buyers

Rank Fund Capital Flow
1
UBS Group
UBS Group
Switzerland
+$13M
2
Corient Private Wealth
Corient Private Wealth
Florida
+$6.6M
3
Vanguard Group
Vanguard Group
Pennsylvania
+$5.74M
4
Susquehanna International Group
Susquehanna International Group
Pennsylvania
+$5.44M
5
Nomura Holdings
Nomura Holdings
Japan
+$5.26M

Top Sellers

Rank Fund Capital Flow
1
Morgan Stanley
Morgan Stanley
New York
-$13.8M
2
PAMP
Polar Asset Management Partners
Ontario, Canada
-$12.3M
3
ISL
Ingalls & Snyder LLC
New York
-$5.67M
4
Two Sigma Advisers
Two Sigma Advisers
New York
-$4.32M
5
Two Sigma Investments
Two Sigma Investments
New York
-$3.52M
Name Holding Trade Value Shares
Change 		Change in
Stake
Renaissance Technologies
151
Renaissance Technologies
New York
– -$1.41M -344,500 Closed
Squarepoint
152
Squarepoint
New York
– -$638K -155,496 Closed
DIG
153
DeepCurrents Investment Group
New York
– -$496K -120,918 Closed
AI
154
Atom Investors
Texas
– -$218K -53,266 Closed
BIG
155
Brooklyn Investment Group
New York
– -$157K -49,197 Closed
State of Wisconsin Investment Board
156
State of Wisconsin Investment Board
Wisconsin
– -$138K -33,678 Closed
BJL
157
Brighton Jones LLC
Washington
– -$129K -31,539 Closed
QC
158
Quadrature Capital
United Kingdom
– -$88.2K -21,533 Closed
GCP
159
GSA Capital Partners
United Kingdom
– -$41K -10,004 Closed
AAP
160
Arax Advisory Partners
Colorado
– -$28.9K -3,361 Closed
MCM
161
MAI Capital Management
Ohio
– -$5.61K -1,369 Closed
Zurich Cantonal Bank
162
Zurich Cantonal Bank
Switzerland
– -$8.61K -1,000 Closed
US Bancorp
163
US Bancorp
Minnesota
– -$205 -50 Closed
CA
164
Clearstead Advisors
Ohio
– -$107 -26 Closed
3 4 5 6
7

OMER Hedge Fund Activity: Q4 2025 in Review

149 of the 8,228 institutional investors tracked by Wall St. Rank reported a position in Omeros (OMER) for Q4 2025, worth a combined $582M — up 332% from $135M a quarter earlier.

Buyers outnumbered sellers: 33 funds opened new OMER positions and 15 closed out — a net gain of 18 holders — while 60 added to existing stakes and 34 trimmed.

The largest buyer was UBS Group, adding an estimated $13M. The largest seller was Morgan Stanley, cutting an estimated $13.8M.

  • 149 institutional investors held Omeros (OMER) as of Q4 2025, up from 133 in Q3 2025.
  • Funds reported $582M of Omeros stock for Q4 2025, up 332% quarter-over-quarter.
  • 33 funds opened new Omeros positions in Q4 2025 and 15 closed out, a net change of +18 holders.
  • The largest Omeros buyer in Q4 2025 was UBS Group, an estimated $13M added.
  • The largest Omeros seller in Q4 2025 was Morgan Stanley, an estimated $13.8M sold.

Based on aggregated 13F filings for Q4 2025.