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Omeros
OMER

127 hedge funds and large institutions have $87.3M invested in Omeros in 2025 Q2 according to their latest regulatory filings, with 17 funds opening new positions, 45 increasing their positions, 35 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed

29% more repeat investments, than reductions

Existing positions increased: 45 | Existing positions reduced: 35

2.1% more ownership

Funds ownership: 47.57% → 49.68% (+2.1%)

7% less funds holding

Funds holding: 136 → 127 (-9)

32% less first-time investments, than exits

New positions opened: 17 | Existing positions closed: 25

55% less call options, than puts

Call options by funds: $1.44M | Put options by funds: $3.19M

61% less capital invested

Capital invested by funds: $227M → $87.3M (-$139M)

Holders
127
Holders Change
-9
Holders Change %
-6.62%
% of All Funds
1.67%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
17
Increased
45
Reduced
35
Closed
25
Calls
$1.44M
Puts
$3.19M
Net Calls
-$1.76M
Net Calls Change
+$434K

Top Buyers

Rank Fund Capital Flow
1
Morgan Stanley
Morgan Stanley
New York
+$2.96M
2
Two Sigma Investments
Two Sigma Investments
New York
+$2.81M
3
DIG
DeepCurrents Investment Group
New York
+$2.63M
4
Two Sigma Advisers
Two Sigma Advisers
New York
+$2.03M
5
Renaissance Technologies
Renaissance Technologies
New York
+$1.91M

Top Sellers

Rank Fund Capital Flow
1
Nomura Holdings
Nomura Holdings
Japan
-$2.94M
2
BlackRock
BlackRock
New York
-$1.65M
3
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$1.45M
4
Corient Private Wealth
Corient Private Wealth
Florida
-$945K
5
State Street
State Street
Massachusetts
-$777K
Name Holding Trade Value Shares
Change 		Change in
Stake
TC
101
Truvestments Capital
Florida
$9.31K – – –
Walleye Capital
102
Walleye Capital
New York
$6.86K +$11.4K +2,285 New
Mirae Asset Global Investments
103
Mirae Asset Global Investments
South Korea
$6.79K +$1.61K +324 +17%
AB
104
Amalgamated Bank
New York
$6K – – –
PA
105
Parallel Advisors
California
$6K – – –
SIS
106
Strategic Investment Solutions
Illinois
$5.47K – – –
Nisa Investment Advisors
107
Nisa Investment Advisors
Missouri
$4.76K -$6K -1,205 -43%
GFM
108
GF Fund Management
China
$4.45K – – –
MCM
109
MAI Capital Management
Ohio
$4.11K – – –
Zurich Cantonal Bank
110
Zurich Cantonal Bank
Switzerland
$4.07K – – –
CAL
111
Capital Analysts LLC
Pennsylvania
$3K – – –
Fifth Third Bancorp
112
Fifth Third Bancorp
Ohio
$3K – – –
Carson Wealth (CWM LLC)
113
Carson Wealth (CWM LLC)
Nebraska
$2K -$7.79K -1,563 -72%
PNC Financial Services Group
114
PNC Financial Services Group
Pennsylvania
$1.96K +$1.69K +340 +109%
Daiwa Securities Group
115
Daiwa Securities Group
Japan
$1K – – –
PW
116
Pandora Wealth
Illinois
$990 – – –
CIAS
117
CBIZ Investment Advisory Services
Ohio
$900 – – –
FDCDDQ
118
Federation des caisses Desjardins du Quebec
Quebec, Canada
$900 – – –
SCM
119
Sterling Capital Management
North Carolina
$879 -$1.81K -363 -55%
SS
120
SBI Securities
Japan
$624 – – –
EWA
121
EverSource Wealth Advisors
Alabama
$549 +$797 +160 +696%
LFG
122
Larson Financial Group
Missouri
$450 -$498 -100 -40%
CIAM
123
Caitong International Asset Management
Hong Kong
$312 -$2.34K -469 -82%
US Bancorp
124
US Bancorp
Minnesota
$300 +$413 +83 +488%
IA
125
IFP Advisors
Florida
$183 – – –
3 4
5
6 7

OMER Hedge Fund Activity: Q2 2025 in Review

127 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Omeros (OMER) for Q2 2025, worth a combined $87.3M — down 61% from $227M a quarter earlier.

Sellers outnumbered buyers: 25 funds closed out of OMER and 17 opened new positions — a net loss of 8 holders — while 35 trimmed existing stakes and 45 added.

The largest buyer was Morgan Stanley, adding an estimated $2.96M. The largest seller was Nomura Holdings, cutting an estimated $2.94M.

  • 127 institutional investors held Omeros (OMER) as of Q2 2025, down from 136 in Q1 2025.
  • Funds reported $87.3M of Omeros stock for Q2 2025, down 61% quarter-over-quarter.
  • 17 funds opened new Omeros positions in Q2 2025 and 25 closed out, a net change of -8 holders.
  • The largest Omeros buyer in Q2 2025 was Morgan Stanley, an estimated $2.96M added.
  • The largest Omeros seller in Q2 2025 was Nomura Holdings, an estimated $2.94M sold.

Based on aggregated 13F filings for Q2 2025.