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Omeros
OMER

127 hedge funds and large institutions have $87.3M invested in Omeros in 2025 Q2 according to their latest regulatory filings, with 17 funds opening new positions, 45 increasing their positions, 35 reducing their positions, and 25 closing their positions.

New
Increased
Maintained
Reduced
Closed

29% more repeat investments, than reductions

Existing positions increased: 45 | Existing positions reduced: 35

2.1% more ownership

Funds ownership: 47.57% → 49.68% (+2.1%)

7% less funds holding

Funds holding: 136 → 127 (-9)

32% less first-time investments, than exits

New positions opened: 17 | Existing positions closed: 25

55% less call options, than puts

Call options by funds: $1.44M | Put options by funds: $3.19M

61% less capital invested

Capital invested by funds: $227M → $87.3M (-$139M)

Holders
127
Holders Change
-9
Holders Change %
-6.62%
% of All Funds
1.67%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
17
Increased
45
Reduced
35
Closed
25
Calls
$1.44M
Puts
$3.19M
Net Calls
-$1.76M
Net Calls Change
+$434K

Top Buyers

Rank Fund Capital Flow
1
Morgan Stanley
Morgan Stanley
New York
+$2.96M
2
Two Sigma Investments
Two Sigma Investments
New York
+$2.81M
3
DIG
DeepCurrents Investment Group
New York
+$2.63M
4
Two Sigma Advisers
Two Sigma Advisers
New York
+$2.03M
5
Renaissance Technologies
Renaissance Technologies
New York
+$1.91M

Top Sellers

Rank Fund Capital Flow
1
Nomura Holdings
Nomura Holdings
Japan
-$2.94M
2
BlackRock
BlackRock
New York
-$1.65M
3
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$1.45M
4
Corient Private Wealth
Corient Private Wealth
Florida
-$945K
5
State Street
State Street
Massachusetts
-$777K
Name Holding Trade Value Shares
Change 		Change in
Stake
EWM
51
Empirical Wealth Management
Washington
$122K +$52.3K +10,500 +35%
CC
52
Corton Capital
Ontario, Canada
$117K +$194K +38,967 New
GCP
53
GSA Capital Partners
United Kingdom
$114K +$190K +38,132 New
SA
54
Sanctuary Advisors
Indiana
$107K +$177K +35,515 New
Deutsche Bank
55
Deutsche Bank
Germany
$105K -$34.5K -6,923 -16%
Comerica Bank
56
Comerica Bank
Texas
$105K – – –
IIM
57
INTECH Investment Management
Florida
$102K +$37.5K +7,538 +28%
MIM
58
MetLife Investment Management
New Jersey
$102K – – –
SCM
59
Stordahl Capital Management
Colorado
$98K – – –
JP Morgan Chase
60
JP Morgan Chase
New York
$96K -$18.9K -3,791 -11%
Mirae Asset Global ETFs Holdings
61
Mirae Asset Global ETFs Holdings
Hong Kong
$95.5K -$6.99K -1,404 -4%
BCM
62
Bridgeway Capital Management
Texas
$95.1K – – –
BJL
63
Brighton Jones LLC
Washington
$92.3K +$314 +63 +0.2%
Cerity Partners
64
Cerity Partners
New York
$86K +$5 +1 +0%
Wealth Enhancement Advisory Services
65
Wealth Enhancement Advisory Services
Minnesota
$83.7K -$220K -44,242 -63%
CCM
66
Coldstream Capital Management
Washington
$80.5K -$60 -12 -0%
BNP Paribas Financial Markets
67
BNP Paribas Financial Markets
France
$75.8K +$106K +21,376 +549%
Citigroup
68
Citigroup
New York
$68.1K -$137K -27,425 -55%
SG Americas Securities
69
SG Americas Securities
New York
$68K -$30.4K -6,110 -21%
Manulife (Manufacturers Life Insurance)
70
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$61.7K +$2.78K +558 +3%
Wolverine Trading
71
Wolverine Trading
Illinois
$56K +$87.1K +17,487 New
State Board of Administration of Florida Retirement System
72
State Board of Administration of Florida Retirement System
Florida
$52.3K – – –
SFI
73
SPC Financial Inc
Maryland
$52.2K – – –
BIM
74
Breakwater Investment Management
Washington
$51.1K – – –
VOYA Investment Management
75
VOYA Investment Management
Georgia
$47.7K +$1.24K +249 +2%
1 2
3
4 5

OMER Hedge Fund Activity: Q2 2025 in Review

127 of the 7,596 institutional investors tracked by Wall St. Rank reported a position in Omeros (OMER) for Q2 2025, worth a combined $87.3M — down 61% from $227M a quarter earlier.

Sellers outnumbered buyers: 25 funds closed out of OMER and 17 opened new positions — a net loss of 8 holders — while 35 trimmed existing stakes and 45 added.

The largest buyer was Morgan Stanley, adding an estimated $2.96M. The largest seller was Nomura Holdings, cutting an estimated $2.94M.

  • 127 institutional investors held Omeros (OMER) as of Q2 2025, down from 136 in Q1 2025.
  • Funds reported $87.3M of Omeros stock for Q2 2025, down 61% quarter-over-quarter.
  • 17 funds opened new Omeros positions in Q2 2025 and 25 closed out, a net change of -8 holders.
  • The largest Omeros buyer in Q2 2025 was Morgan Stanley, an estimated $2.96M added.
  • The largest Omeros seller in Q2 2025 was Nomura Holdings, an estimated $2.94M sold.

Based on aggregated 13F filings for Q2 2025.