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Omeros
OMER

133 hedge funds and large institutions have $135M invested in Omeros in 2025 Q3 according to their latest regulatory filings, with 15 funds opening new positions, 58 increasing their positions, 30 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

93% more repeat investments, than reductions

Existing positions increased: 58 | Existing positions reduced: 30

67% more first-time investments, than exits

New positions opened: 15 | Existing positions closed: 9

54% more capital invested

Capital invested by funds: $87.3M → $135M (+$47.4M)

5% more funds holding

Funds holding: 127 → 133 (+6)

5% less call options, than puts

Call options by funds: $10.4M | Put options by funds: $10.9M

1.41% less ownership

Funds ownership: 49.68% → 48.27% (-1.4%)

Holders
133
Holders Change
+6
Holders Change %
+4.72%
% of All Funds
1.75%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
15
Increased
58
Reduced
30
Closed
9
Calls
$10.4M
Puts
$10.9M
Net Calls
-$517K
Net Calls Change
+$1.24M

Top Buyers

Rank Fund Capital Flow
1
PAMP
Polar Asset Management Partners
Ontario, Canada
+$5.95M
2
Morgan Stanley
Morgan Stanley
New York
+$2.52M
3
BlackRock
BlackRock
New York
+$1.59M
4
JP Morgan Chase
JP Morgan Chase
New York
+$1.52M
5
Stifel Financial
Stifel Financial
Missouri
+$1.15M

Top Sellers

Rank Fund Capital Flow
1
D.E. Shaw & Co
D.E. Shaw & Co
New York
-$2.55M
2
DIG
DeepCurrents Investment Group
New York
-$1.62M
3
Marshall Wace
Marshall Wace
United Kingdom
-$1.1M
4
UBS Group
UBS Group
Switzerland
-$632K
5
GCM
Graham Capital Management
Connecticut
-$262K
Name Holding Trade Value Shares
Change 		Change in
Stake
BPWM
26
Badgley Phelps Wealth Managers
Washington
$1.08M +$564K +142,118 +117%
Wellington Management Group
27
Wellington Management Group
Massachusetts
$797K +$123K +31,034 +19%
SPS
28
Susquehanna Portfolio Strategies
Pennsylvania
$701K +$115K +29,030 +20%
Bank of New York Mellon
29
Bank of New York Mellon
New York
$666K +$57.4K +14,463 +10%
Squarepoint
30
Squarepoint
New York
$638K +$266K +67,021 +76%
NFSG
31
Newbridge Financial Services Group
Florida
$551K +$163K +41,090 +44%
Wells Fargo
32
Wells Fargo
California
$550K +$46.5K +11,717 +10%
Barclays
33
Barclays
United Kingdom
$541K +$28.2K +7,117 +6%
BHCM
34
Brevan Howard Capital Management
Jersey
$531K +$95.6K +24,094 +23%
Invesco
35
Invesco
Georgia
$501K +$21.4K +5,387 +5%
DIG
36
DeepCurrents Investment Group
New York
$496K -$1.62M -407,211 -77%
Ameriprise
37
Ameriprise
Minnesota
$478K – – –
Susquehanna International Group
38
Susquehanna International Group
Pennsylvania
$453K -$22K -5,547 -5%
RhumbLine Advisers
39
RhumbLine Advisers
Massachusetts
$434K +$28K +7,048 +7%
Group One Trading
40
Group One Trading
Illinois
$403K -$82.1K -20,692 -17%
HighTower Advisors
41
HighTower Advisors
Illinois
$390K +$103K +26,000 +38%
T. Rowe Price Associates
42
T. Rowe Price Associates
Maryland
$368K +$50.5K +12,737 +17%
BNP Paribas Financial Markets
43
BNP Paribas Financial Markets
France
$361K +$249K +62,845 +249%
N
44
Nuveen
North Carolina
$359K – – –
AllianceBernstein
45
AllianceBernstein
Tennessee
$277K – – –
AFG
46
American Financial Group
Ohio
$263K – – –
MWM
47
Mindset Wealth Management
Indiana
$246K – – –
MML Investors Services
48
MML Investors Services
Massachusetts
$243K +$38.1K +9,600 +19%
BCM
49
Bridgeway Capital Management
Texas
$233K +$99.2K +25,000 +79%
AI
50
Atom Investors
Texas
$218K +$163K +41,133 +339%
1
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OMER Hedge Fund Activity: Q3 2025 in Review

133 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Omeros (OMER) for Q3 2025, worth a combined $135M — up 54% from $87.3M a quarter earlier.

Buyers outnumbered sellers: 15 funds opened new OMER positions and 9 closed out — a net gain of 6 holders — while 58 added to existing stakes and 30 trimmed.

The largest buyer was Polar Asset Management Partners, opening a new position worth an estimated $5.95M. The largest seller was D.E. Shaw & Co, cutting an estimated $2.55M.

  • 133 institutional investors held Omeros (OMER) as of Q3 2025, up from 127 in Q2 2025.
  • Funds reported $135M of Omeros stock for Q3 2025, up 54% quarter-over-quarter.
  • 15 funds opened new Omeros positions in Q3 2025 and 9 closed out, a net change of +6 holders.
  • The largest Omeros buyer in Q3 2025 was Polar Asset Management Partners, an estimated $5.95M added.
  • The largest Omeros seller in Q3 2025 was D.E. Shaw & Co, an estimated $2.55M sold.

Based on aggregated 13F filings for Q3 2025.