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NUVB

Name Holding Trade Value Shares
Change 		Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$311M +$361M +32,284,495 New
OFM
2
Omega Fund Management
Massachusetts
$295M +$315M +28,212,376 New
EC
3
EcoR1 Capital
California
$138M +$148M +13,247,017 New
BG
4
Baupost Group
Massachusetts
$82.4M +$96.4M +8,623,021 New
APM
5
Avidity Partners Management
Texas
$78.6M +$84.1M +7,521,941 New
Vanguard Group
6
Vanguard Group
Pennsylvania
$72.7M +$77.8M +6,957,156 New
Citadel Advisors
7
Citadel Advisors
Florida
$68.8M +$45.7M +4,086,050 +163%
RG
8
Redmile Group
California
$47.5M +$50.8M +4,541,009 New
BC
9
Boxer Capital
California
$45.4M +$39.6M +3,541,009 +443%
ACM
10
Abrams Capital Management
Massachusetts
$34M +$42.6M +3,811,513 New
DM
11
Deerfield Management
New York
$31.4M +$33.5M +3,000,000 New
PA
12
Perceptive Advisors
New York
$29M +$34M +3,041,004 New
ACM
13
Aisling Capital Management
New York
$26.6M +$28.4M +2,541,009 New
FCM
14
Farallon Capital Management
California
$26.1M – – –
ABG
15
Ally Bridge Group
New York
$20.9M +$22.4M +2,000,000 New
BlackRock
16
BlackRock
New York
$15.1M +$8.28M +740,434 +106%
Millennium Management
17
Millennium Management
New York
$14.4M +$12.1M +1,085,824 +367%
Hudson Bay Capital Management
18
Hudson Bay Capital Management
Connecticut
$12.3M +$11.1M +992,399 +528%
Alyeska Investment Group
19
Alyeska Investment Group
Illinois
$10.4M +$10.4M +928,409 +1,297%
CH
20
CVI Holdings
Delaware
$10.4M +$11.2M +1,000,000 New
Ensign Peak Advisors
21
Ensign Peak Advisors
Utah
$8.87M +$5.59M +500,000 +143%
Franklin Resources
22
Franklin Resources
California
$8.36M +$8.94M +800,000 New
O
23
OrbiMed
New York
$8.36M +$8.94M +800,000 New
Wellington Management Group
24
Wellington Management Group
Massachusetts
$8.22M +$9.04M +808,325 New
Ameriprise
25
Ameriprise
Minnesota
$7.61M +$8.14M +727,836 New
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