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Lexicon Pharmaceuticals
LXRX

Overview Fund Activity

122 hedge funds and large institutions have $243M invested in Lexicon Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 28 funds opening new positions, 32 increasing their positions, 36 reducing their positions, and 33 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
122
Holders Change
-5
Holders Change %
-3.94%
% of All Funds
1.64%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
28
Increased
32
Reduced
36
Closed
33
Calls
$805K
Puts
$145K
Net Calls
+$660K
Net Calls Change
+$354K

Top Buyers

1
Fidelity Investments
Fidelity Investments
Massachusetts
$36.1M
2
SC
Sessa Capital
New York
$2.84M
3
GCP
GSA Capital Partners
United Kingdom
$2.68M
4
Millennium Management
Millennium Management
New York
$1.55M
5
Jane Street
Jane Street
New York
$761K

Top Sellers

1
BlackRock
BlackRock
New York
$3.17M
2
SSA
Schonfeld Strategic Advisors
New York
$4.33M
3
State Street
State Street
Massachusetts
$774K
4
UBS Group
UBS Group
Switzerland
$379K
5
Geode Capital Management
Geode Capital Management
Massachusetts
$2.25M
Name Holding Trade Value Shares
Change 		Shares
Change %
Nisa Investment Advisors
101
Nisa Investment Advisors
Missouri
$2.45K +$1.88K +1,992 +332%
Raymond James Financial
102
Raymond James Financial
Florida
$1.96K -$9.3K -9,836 -83%
QPBE
103
Quintet Private Bank (Europe)
Luxembourg
$1.82K – – –
Jones Financial Companies
104
Jones Financial Companies
Missouri
$1.67K – – –
PNC Financial Services Group
105
PNC Financial Services Group
Pennsylvania
$1.38K – – –
PWA
106
Physician Wealth Advisors
Utah
$1.34K +$1.34K +1,412 New
RWM
107
Rialto Wealth Management
New York
$1.24K – – –
EWA
108
EverSource Wealth Advisors
Alabama
$1.1K +$220 +233 +25%
Daiwa Securities Group
109
Daiwa Securities Group
Japan
$1K – – –
AW
110
Avion Wealth
Texas
$1K +$149 +199 +18%
FFA
111
Farther Finance Advisors
California
$948 +$946 +1,000 +50,000%
GRP
112
Global Retirement Partners
California
$946 +$946 +1,000 New
TWD
113
True Wealth Design
Ohio
$703 +$117 +124 +20%
FFO
114
Fortitude Family Office
Arizona
$668 +$668 +706 New
Osaic Holdings
115
Osaic Holdings
Arizona
$549 -$148 -200 -21%
Northwestern Mutual Wealth Management
116
Northwestern Mutual Wealth Management
Wisconsin
$473 – – –
SR
117
Syntax Research
Florida
$135 – – –
Comerica Bank
118
Comerica Bank
Texas
$115 – – –
LFG
119
Larson Financial Group
Missouri
$95 – – –
CIAS
120
CBIZ Investment Advisory Services
Ohio
$67 – – –
IA
121
IFP Advisors
Florida
$1 +$1 +1 New
TCM
122
Tang Capital Management
California
– -$530K -1,150,268 Closed
Acadian Asset Management
123
Acadian Asset Management
Massachusetts
– -$263K -573,688 Closed
BP
124
BBR Partners
New York
– -$263K -570,000 Closed
NCM
125
Nantahala Capital Management
Connecticut
– -$212K -460,850 Closed
3 4
5
6 7