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Lexicon Pharmaceuticals
LXRX

127 hedge funds and large institutions have $122M invested in Lexicon Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 31 funds opening new positions, 34 increasing their positions, 32 reducing their positions, and 30 closing their positions.

New
Increased
Maintained
Reduced
Closed

588% more call options, than puts

Call options by funds: $358K | Put options by funds: $52K

6% more repeat investments, than reductions

Existing positions increased: 34 | Existing positions reduced: 32

3% more first-time investments, than exits

New positions opened: 31 | Existing positions closed: 30

0% more funds holding

Funds holding: 127 → 127 (0)

0% more funds holding in top 10

Funds holding in top 10: 1 → 1 (0)

8.82% less ownership

Funds ownership: 82.35% → 73.52% (-8.8%)

44% less capital invested

Capital invested by funds: $220M → $122M (-$97.7M)

Holders
127
Holders Change
–
Holders Change %
0%
% of All Funds
1.7%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
31
Increased
34
Reduced
32
Closed
30
Calls
$358K
Puts
$52K
Net Calls
+$306K
Net Calls Change
-$78K

Top Buyers

Rank Fund Capital Flow
1
CIBC Private Wealth Group
CIBC Private Wealth Group
Georgia
+$1.41M
2
UBS Group
UBS Group
Switzerland
+$889K
3
AQR Capital Management
AQR Capital Management
Connecticut
+$740K
4
GCP
GSA Capital Partners
United Kingdom
+$509K
5
MAM
Monaco Asset Management
Monaco
+$463K

Top Sellers

Rank Fund Capital Flow
1
Fidelity Investments
Fidelity Investments
Massachusetts
-$11M
2
Point72 Asset Management
Point72 Asset Management
Connecticut
-$6.64M
3
NCM
Nantahala Capital Management
Connecticut
-$3.88M
4
NMC
NEA Management Company
Maryland
-$1.76M
5
PA
Pinnacle Associates
New York
-$865K
Name Holding Trade Value Shares
Change 		Change in
Stake
Jones Financial Companies
101
Jones Financial Companies
Missouri
$1.16K +$1.2K +1,900 +1,338%
Royal Bank of Canada
102
Royal Bank of Canada
Ontario, Canada
$1K -$4.26K -6,752 -68%
AB
103
Amalgamated Bank
New York
$1K – – –
Daiwa Securities Group
104
Daiwa Securities Group
Japan
$1K – – –
QPBE
105
Quintet Private Bank (Europe)
Luxembourg
$888 – – –
Optiver Holding
106
Optiver Holding
Netherlands
$849 +$406 +643 +54%
PNC Financial Services Group
107
PNC Financial Services Group
Pennsylvania
$673 +$852 +1,350 +1,216%
CCM
108
Coldstream Capital Management
Washington
$640 +$876 +1,388 New
RWM
109
Rialto Wealth Management
New York
$606 +$828 +1,313 New
SCM
110
Sterling Capital Management
North Carolina
$590 -$755 -1,197 -48%
US Bancorp
111
US Bancorp
Minnesota
$499 -$342 -542 -33%
PS
112
Pinney & Scofield
Massachusetts
$461 – – –
Osaic Holdings
113
Osaic Holdings
Arizona
$433 +$126 +200 +27%
EWA
114
EverSource Wealth Advisors
Alabama
$429 +$567 +898 +2,806%
TWD
115
True Wealth Design
Ohio
$286 +$391 +619 New
Nisa Investment Advisors
116
Nisa Investment Advisors
Missouri
$276 +$379 +600 New
Northwestern Mutual Wealth Management
117
Northwestern Mutual Wealth Management
Wisconsin
$230 – – –
Citadel Advisors
118
Citadel Advisors
Florida
$187 -$16K -25,426 -98%
SIC
119
SJS Investment Consulting
Ohio
$185 – – –
SR
120
Syntax Research
Florida
$66 – – –
Comerica Bank
121
Comerica Bank
Texas
$56 – – –
LFG
122
Larson Financial Group
Missouri
$46 – – –
CIAS
123
CBIZ Investment Advisory Services
Ohio
$33 – – –
NA
124
NewEdge Advisors
Louisiana
$2 – – –
FFA
125
Farther Finance Advisors
California
$1 – – –
3 4
5
6 7

LXRX Hedge Fund Activity: Q1 2025 in Review

127 of the 7,457 institutional investors tracked by Wall St. Rank reported a position in Lexicon Pharmaceuticals (LXRX) for Q1 2025, worth a combined $122M — down 44% from $220M a quarter earlier.

Buyers outnumbered sellers: 31 funds opened new LXRX positions and 30 closed out — a net gain of 1 holder — while 34 added to existing stakes and 32 trimmed.

The largest buyer was CIBC Private Wealth Group, opening a new position worth an estimated $1.41M. The largest seller was Fidelity Investments, cutting an estimated $11M.

  • 127 institutional investors held Lexicon Pharmaceuticals (LXRX) as of Q1 2025, unchanged from Q4 2024.
  • Funds reported $122M of Lexicon Pharmaceuticals stock for Q1 2025, down 44% quarter-over-quarter.
  • 31 funds opened new Lexicon Pharmaceuticals positions in Q1 2025 and 30 closed out, a net change of +1 holder.
  • The largest Lexicon Pharmaceuticals buyer in Q1 2025 was CIBC Private Wealth Group, an estimated $1.41M added.
  • The largest Lexicon Pharmaceuticals seller in Q1 2025 was Fidelity Investments, an estimated $11M sold.

Based on aggregated 13F filings for Q1 2025.