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Lexicon Pharmaceuticals

124 hedge funds and large institutions have $299M invested in Lexicon Pharmaceuticals in 2025 Q4 according to their latest regulatory filings, with 22 funds opening new positions, 29 increasing their positions, 40 reducing their positions, and 16 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more first-time investments, than exits

New positions opened: | Existing positions closed:

more funds holding

Funds holding:

more ownership

Funds ownership:

0% more funds holding in top 10

Funds holding in top 10: 11 (0)

13% less capital invested

Capital invested by funds: $344M → $299M (-$44.9M)

28% less repeat investments, than reductions

Existing positions increased: 29 | Existing positions reduced: 40

Holders
124
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
1
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$1.13M
Puts
$289K
Net Calls
Net Calls Change

Top Buyers

1 +$3.65M
2 +$1.74M
3 +$1.73M
4
Millennium Management
Millennium Management
New York
+$1.36M
5
Goldman Sachs
Goldman Sachs
New York
+$1.18M
Name Holding Trade Value Shares
Change
Change in
Stake
Bank of Montreal
51
Bank of Montreal
Ontario, Canada
$80.5K
VPIM
52
Vanguard Personalized Indexing Management
California
$76.6K
SPWM
53
Straight Path Wealth Management
Michigan
$72.1K
SOW
54
State of Wyoming
Wyoming
$69.7K
Squarepoint
55
Squarepoint
New York
$69.5K
Optiver Holding
56
Optiver Holding
Netherlands
$60.5K
FGA
57
Fortis Group Advisors
New Jersey
$58K
RS
58
R Squared
Hong Kong
$53.6K
BFM
59
Boothbay Fund Management
New York
$51K
WS
60
Wedbush Securities
California
$47K
KW
61
KWB Wealth
California
$46.7K
CFM
62
Catalyst Funds Management
Australia
$46.3K
CIBC Asset Management
63
CIBC Asset Management
Ontario, Canada
$45.4K
VF
64
Virtu Financial
New York
$42K
UOTTAIMCU
65
University of Texas/Texas AM Investment Management Co (UTIMCO)
Texas
$41.1K
Prudential Financial
66
Prudential Financial
New Jersey
$38.9K
EC
67
EntryPoint Capital
New York
$38.7K
VWWMG
68
Vermillion & White Wealth Management Group
Pennsylvania
$36.8K
LSA
69
Leonteq Securities AG
Switzerland
$34.5K
Pathstone Holdings
70
Pathstone Holdings
New Jersey
$34.5K
TRCT
71
Tower Research Capital (TRC)
New York
$33.5K
PA
72
Pinnacle Associates
New York
$33.4K
SNBOSCI
73
Security National Bank of Sioux City Iowa
Iowa
$30.6K
OC
74
Oppenheimer & Co
New York
$27K
Cambridge Investment Research Advisors
75
Cambridge Investment Research Advisors
Iowa
$25K