|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$513M
|
+$278M
|
+5,914,329
|
+89%
|
|
|
2
|
HHLR Advisors
Grand Cayman,
Cayman Islands
|
$210M
|
+$32.9M
|
+700,000
|
+16%
|
|
|
3
|
|
$152M
|
+$27.4M
|
+583,851
|
+19%
|
|
|
4
|
Janus Henderson Group
London,
|
$152M
|
+$171M
|
+3,633,649
|
+3,989%
|
|
|
5
|
Capital International Investors
Los Angeles,
California
|
$118M
|
-$7.57M
|
-161,206
|
-5%
|
|
|
6
|
Capital World Investors
Los Angeles,
California
|
$97.5M
|
-$119K
|
-2,545
|
-0.1%
|
|
|
7
|
Federated Hermes
Pittsburgh,
Pennsylvania
|
$95.4M
|
+$10.6M
|
+225,000
|
+11%
|
|
|
8
|
RA Capital Management
Boston,
Massachusetts
|
$95.4M
|
+$110M
|
+2,338,610
|
New
|
|
|
9
|
Wellington Management Group
Boston,
Massachusetts
|
$67.4M
|
-$44.8M
|
-955,523
|
-37%
|
|
|
10
|
Johnson & Johnson
New Brunswick,
New Jersey
|
$66.5M
|
–
|
–
|
–
|
|
|
11
|
AllianceBernstein
Nashville,
Tennessee
|
$62.7M
|
+$3.32M
|
+70,651
|
+5%
|
|
|
12
|
Matthews International Capital Management
San Francisco,
California
|
$59.8M
|
+$11.5M
|
+244,111
|
+20%
|
|
|
13
|
Artisan Partners
Milwaukee,
Wisconsin
|
$57.4M
|
-$14.1M
|
-299,749
|
-18%
|
|
|
14
|
Capital International Inc
Los Angeles,
California
|
$50.8M
|
+$370K
|
+7,891
|
+0.6%
|
|
|
15
|
Paradigm Biocapital Advisors
New York
|
$43.9M
|
+$4.6M
|
+97,995
|
+10%
|
|
|
16
|
ArrowMark Colorado Holdings
Denver,
Colorado
|
$41.5M
|
+$38.1M
|
+811,110
|
+395%
|
|
|
17
|
TimesSquare Capital Management
New York
|
$38.4M
|
+$39.9M
|
+849,800
|
+929%
|
|
|
18
|
|
$36.4M
|
+$20.5M
|
+437,505
|
+96%
|
|
|
19
|
State Street
Boston,
Massachusetts
|
$31.2M
|
+$2.72M
|
+58,042
|
+8%
|
|
|
20
|
Millennium Management
New York
|
$28.1M
|
+$20.8M
|
+444,096
|
+182%
|
|
|
21
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$26.8M
|
+$4.16M
|
+88,643
|
+16%
|
|
|
22
|
Bellevue Group
Kuesnacht,
Switzerland
|
$25.5M
|
-$234K
|
-4,978
|
-0.8%
|
|
|
23
|
Bridgewater Associates
Westport,
Connecticut
|
$25.2M
|
+$2.15M
|
+45,763
|
+8%
|
|
|
24
|
Adage Capital Partners
Boston,
Massachusetts
|
$23.6M
|
-$29.1M
|
-620,948
|
-52%
|
|
|
25
|
|
$22.7M
|
+$6.49M
|
+138,330
|
+33%
|
|
