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Krystal Biotech

332 hedge funds and large institutions have $7.01B invested in Krystal Biotech in 2025 Q4 according to their latest regulatory filings, with 81 funds opening new positions, 111 increasing their positions, 105 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed

more first-time investments, than exits

New positions opened: | Existing positions closed:

more call options, than puts

Call options by funds: $ | Put options by funds: $

more capital invested

Capital invested by funds: $ → $

more funds holding

Funds holding:

14% more funds holding in top 10

Funds holding in top 10: 78 (+1)

1.26% more ownership

Funds ownership: 96.77%98.03% (+1.3%)

6% more repeat investments, than reductions

Existing positions increased: 111 | Existing positions reduced: 105

Holders
332
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
8
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$53M
Puts
$21.6M
Net Calls
Net Calls Change

Top Buyers

1 +$86.1M
2 +$47.8M
3 +$44.1M
4
ACA
Avoro Capital Advisors
New York
+$23.4M
5
Franklin Resources
Franklin Resources
California
+$22.3M

Top Sellers

1 -$67M
2 -$52.7M
3 -$42.1M
4
UBS AM
UBS AM
Illinois
-$35.6M
5
Millennium Management
Millennium Management
New York
-$28.2M
Name Holding Trade Value Shares
Change
Change in
Stake
SPS
151
Susquehanna Portfolio Strategies
Pennsylvania
$1.01M
SFCML
152
Seven Fleet Capital Management LP
California
$986K
P8IP
153
Pier 88 Investment Partners
California
$979K
Zurich Cantonal Bank
154
Zurich Cantonal Bank
Switzerland
$953K
Fisher Asset Management
155
Fisher Asset Management
Washington
$933K
MSRPS
156
Maryland State Retirement & Pension System
Maryland
$930K
Amundi
157
Amundi
France
$926K
BFM
158
Boothbay Fund Management
New York
$870K
Renaissance Technologies
159
Renaissance Technologies
New York
$814K
Teacher Retirement System of Texas
160
Teacher Retirement System of Texas
Texas
$794K
William Blair & Company
161
William Blair & Company
Illinois
$783K
BBA
162
Baader Bank Aktiengesellschaft
Germany
$769K
DnB Asset Management
163
DnB Asset Management
Norway
$763K
RAM
164
Resona Asset Management
Japan
$754K
OL
165
Odyssean LLC
Connecticut
$743K
CWS
166
Confluence Wealth Services
Pennsylvania
$720K
N
167
Natixis
France
$720K
QCM
168
Quantinno Capital Management
New York
$716K
BHCM
169
Brevan Howard Capital Management
Jersey
$715K
OF
170
Optimize Financial
California
$704K
VIA
171
Virtus Investment Advisers
Connecticut
$688K
ET
172
Entropy Technologies
New York
$617K
OSAM
173
O'Shaughnessy Asset Management
Connecticut
$597K
CG
174
Cynosure Group
Utah
$593K
Janney Montgomery Scott
175
Janney Montgomery Scott
Pennsylvania
$591K