|
1
|
Fidelity Investments
Boston,
Massachusetts
|
$316M
|
–
|
–
|
–
|
|
|
2
|
Wellington Management Group
Boston,
Massachusetts
|
$280M
|
+$3.76M
|
+286,529
|
+1%
|
|
|
3
|
Janus Henderson Investors US
Denver,
Colorado
|
$238M
|
+$9.38M
|
+715,255
|
+4%
|
|
|
4
|
|
$192M
|
–
|
–
|
–
|
|
|
5
|
Vanguard Group
Malvern,
Pennsylvania
|
$128M
|
+$7.11M
|
+542,146
|
+6%
|
|
|
6
|
|
$115M
|
-$8.57M
|
-653,503
|
-7%
|
|
|
7
|
Deutsche Bank
Frankfurt Am Main Ge,
Germany
|
$107M
|
-$5.52M
|
-420,664
|
-5%
|
|
|
8
|
BlackRock Fund Advisors
San Francisco,
California
|
$90.7M
|
+$5.17M
|
+393,708
|
+6%
|
|
|
9
|
State Street
Boston,
Massachusetts
|
$53.7M
|
+$6.14M
|
+468,329
|
+13%
|
|
|
10
|
BlackRock Institutional Trust
San Francisco,
California
|
$51.6M
|
+$34.5K
|
+2,626
|
+0.1%
|
|
|
11
|
State of Wisconsin Investment Board
Madison,
Wisconsin
|
$49.7M
|
-$9.72M
|
-740,883
|
-17%
|
|
|
12
|
T. Rowe Price Associates
Baltimore,
Maryland
|
$42.1M
|
+$26M
|
+1,981,596
|
+171%
|
|
|
13
|
Millennium Management
New York
|
$38.1M
|
-$4.52M
|
-344,222
|
-11%
|
|
|
14
|
BVF Inc
San Francisco,
California
|
$34.7M
|
-$45.8M
|
-3,489,706
|
-57%
|
|
|
15
|
Northern Trust
Chicago,
Illinois
|
$26M
|
+$396K
|
+30,158
|
+2%
|
|
|
16
|
Capital World Investors
Los Angeles,
California
|
$23.6M
|
-$2.04M
|
-155,220
|
-8%
|
|
|
17
|
Fred Alger Management
New York
|
$23.1M
|
-$6.9M
|
-526,065
|
-23%
|
|
|
18
|
Asset Management One
Tokyo,
Japan
|
$19.1M
|
-$24.7K
|
-1,883
|
-0.1%
|
|
|
19
|
|
$19.1M
|
+$17.1M
|
+1,305,117
|
+1,105%
|
|
|
20
|
Sector Gamma AS
Oslo,
Norway
|
$18.6M
|
+$266K
|
+20,298
|
+1%
|
|
|
21
|
|
$16.5M
|
+$14.8M
|
+1,128,545
|
+1,132%
|
|
|
22
|
EcoR1 Capital
San Francisco,
California
|
$14.4M
|
–
|
–
|
–
|
|
|
23
|
|
$14M
|
+$2.42M
|
+184,696
|
+21%
|
|
|
24
|
Bridger Management
New York
|
$13.4M
|
+$13.2M
|
+1,003,532
|
New
|
|
|
25
|
Tekla Capital Management
Boston,
Massachusetts
|
$12.3M
|
–
|
–
|
–
|
|
