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Structure Therapeutics
GPCR
GPCR
197 hedge funds and large institutions have $4.58B invested in Structure Therapeutics in 2025 Q4 according to their latest regulatory filings, with 71 funds opening new positions, 52 increasing their positions, 62 reducing their positions, and 27 closing their positions.
New
Increased
Maintained
Reduced
Closed
433% more funds holding in top 10
Funds holding in top 10: 3 → 16 (+13)
243% more call options, than puts
Call options by funds: $62.6M | Put options by funds: $18.2M
189% more capital invested
Capital invested by funds: $1.58B → $4.58B (+$3B)
163% more first-time investments, than exits
New positions opened: 71 | Existing positions closed: 27
26% more funds holding
Funds holding: 156 → 197 (+41)
10.07% more ownership
Funds ownership: 98.33% → 108.4% (+10%)
16% less repeat investments, than reductions
Existing positions increased: 52 | Existing positions reduced: 62
Holders
197
Holders Change
+41
Holders Change %
+26.28%
% of All Funds
2.4%
Holding in Top 10
16
Holding in Top 10 Change
+13
Holding in Top 10 Change %
+433.33%
% of All Funds
0.19%
New
71
Increased
52
Reduced
62
Closed
27
Calls
$62.6M
Puts
$18.2M
Net Calls
+$44.4M
Net Calls Change
+$33.8M
Top Buyers
| 1 |
Fidelity Investments
Boston,
Massachusetts
|
+$141M |
| 2 |
Morgan Stanley
New York
|
+$61.7M |
| 3 |
Wellington Management Group
Boston,
Massachusetts
|
+$58.5M |
| 4 |
ACA
Avoro Capital Advisors
New York
|
+$57.2M |
| 5 |
T. Rowe Price Associates
Baltimore,
Maryland
|
+$56.4M |
Top Sellers
| 1 |
Millennium Management
New York
|
-$45.8M |
| 2 |
RCM
RA Capital Management
Boston,
Massachusetts
|
-$42.5M |
| 3 |
Ameriprise
Minneapolis,
Minnesota
|
-$38.3M |
| 4 |
Invesco
Atlanta,
Georgia
|
-$18M |
| 5 |
CCM
Catalio Capital Management
New York
|
-$16.3M |
