Two Sigma Advisers
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Two Sigma Advisers’s Structure Therapeutics GPCR Stock Holding History

Two Sigma Advisers’s Portfolio GPCR Stock Details GPCR Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2025
Q4 		– Sell
-249,299
Closed -$6.98M – 2448
2025
Q3 		$6.98M Buy
249,299
+213,199
+591% +$4.25M 0.01% 623
2025
Q2 		$749K Buy
+36,100
New +$794K ﹤0.01% 1571

Other funds holding GPCR

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
Wellington Management Group
Wellington Management Group Boston, Massachusetts $535B AUM 26.23% 1-Year Est. Return
ACA
Avoro Capital Advisors New York $10.2B AUM 149.19% 1-Year Est. Return
Janus Henderson Group
Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return
DTC
Deep Track Capital Greenwich, Connecticut $6.12B AUM 144% 1-Year Est. Return
BI
BVF Inc San Francisco, California $3.14B AUM 249.53% 1-Year Est. Return
Morgan Stanley
Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return
T. Rowe Price Associates
T. Rowe Price Associates Baltimore, Maryland $865B AUM 30.76% 1-Year Est. Return
DCM
Driehaus Capital Management Chicago, Illinois $13.6B AUM 173.98% 1-Year Est. Return
BBA
Baker Bros. Advisors New York $17.4B AUM 131.5% 1-Year Est. Return

Two Sigma Advisers's GPCR Position: Q4 2025 in Review

Two Sigma Advisers sold out of Structure Therapeutics (GPCR) in Q4 2025, closing a stake of 249,299 shares — an estimated $6.98M sold.

Two Sigma Advisers first reported a position in GPCR in Q2 2025 and held it in 2 quarters. The position peaked at $6.98M in Q3 2025. 197 funds tracked by Wall St. Rank hold GPCR as of Q4 2025.

  • Two Sigma Advisers reported no remaining Structure Therapeutics position as of Q4 2025 after selling out during the quarter.
  • Two Sigma Advisers sold 249,299 Structure Therapeutics shares in Q4 2025, an estimated $6.98M.
  • Two Sigma Advisers first reported a position in Structure Therapeutics in Q2 2025 and held it in 2 quarters.
  • Two Sigma Advisers's Structure Therapeutics position peaked at $6.98M in Q3 2025.
  • 197 funds tracked by Wall St. Rank held Structure Therapeutics as of Q4 2025.

Based on Two Sigma Advisers's 13F filing for Q4 2025, filed 17 Feb 2026.