Structure Therapeutics
GPCR
150 hedge funds and large institutions have $981M invested in Structure Therapeutics in 2025 Q1 according to their latest regulatory filings, with 23 funds opening new positions, 46 increasing their positions, 50 reducing their positions, and 36 closing their positions.
6% more call options, than puts
Call options by funds: $12.4M | Put options by funds: $11.7M
8% less repeat investments, than reductions
Existing positions increased: 46 | Existing positions reduced: 50
2.8% less ownership
Funds ownership: 35.31% → 32.51% (-2.8%)
9% less funds holding
Funds holding: 164 → 150 (-14)
36% less first-time investments, than exits
New positions opened: 23 | Existing positions closed: 36
40% less capital invested
Capital invested by funds: $1.65B → $981M (-$665M)
80% less funds holding in top 10
Funds holding in top 10: 5 → 1 (-4)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
DTC
Deep Track Capital
Greenwich,
Connecticut
|
+$31.8M |
| 2 |
Morgan Stanley
New York
|
+$7.48M |
| 3 |
RAM
Readystate Asset Management
Chicago,
Illinois
|
+$6.66M |
| 4 |
Handelsbanken Fonder
Stockholm,
Sweden
|
+$5.27M |
| 5 |
Balyasny Asset Management
Chicago,
Illinois
|
+$4.96M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Capital Research Global Investors
Los Angeles,
California
|
-$33.6M |
| 2 |
Federated Hermes
Pittsburgh,
Pennsylvania
|
-$21.4M |
| 3 |
DCM
Driehaus Capital Management
Chicago,
Illinois
|
-$19.2M |
| 4 |
T. Rowe Price Associates
Baltimore,
Maryland
|
-$15.1M |
| 5 |
BCM
Boxer Capital Management
San Diego,
California
|
-$13.6M |
| Name | Holding | Trade Value |
Shares Change |
Change in Stake |
|
|---|---|---|---|---|---|
176
SG Americas Securities
New York
| – | -$148K | -5,445 | Closed |
|
|
VI
177
Vestcor Inc
Fredericton,
New Brunswick, Canada
| – | -$127K | -4,700 | Closed |
|
|
BPCE
178
Bank Pictet & Cie (Europe)
Frankfurt Am Main,
Germany
| – | -$112K | -4,143 | Closed |
|
|
VEA
179
Virtus ETF Advisers
New York
| – | -$60.8K | -2,242 | Closed |
|
|
JFG
180
Jefferies Financial Group
New York
| – | -$54.2K | -2,000 | Closed |
|
|
RS
181
R Squared
Central,
Hong Kong
| – | -$18.4K | -680 | Closed |
|
|
SSG
182
Summit Securities Group
New York
| – | -$6.67K | -246 | Closed |
|
|
VWM
183
Vermillion Wealth Management
Rosemount,
Minnesota
| – | -$2.71K | -100 | Closed |
|
|
FFA
184
Fairfield Financial Advisors
Wellesley,
Massachusetts
| – | -$1.6K | -59 | Closed |
|
|
APW
185
Aventura Private Wealth
Aventura,
Florida
| – | -$759 | -28 | Closed |
|
GPCR Hedge Fund Activity: Q1 2025 in Review
150 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Structure Therapeutics (GPCR) for Q1 2025, worth a combined $981M — down 40% from $1.65B a quarter earlier.
Sellers outnumbered buyers: 36 funds closed out of GPCR and 23 opened new positions — a net loss of 13 holders — while 50 trimmed existing stakes and 46 added.
The largest buyer was Deep Track Capital, adding an estimated $31.8M. The largest seller was Capital Research Global Investors, cutting an estimated $33.6M.
- 150 institutional investors held Structure Therapeutics (GPCR) as of Q1 2025, down from 164 in Q4 2024.
- Funds reported $981M of Structure Therapeutics stock for Q1 2025, down 40% quarter-over-quarter.
- 23 funds opened new Structure Therapeutics positions in Q1 2025 and 36 closed out, a net change of -13 holders.
- The largest Structure Therapeutics buyer in Q1 2025 was Deep Track Capital, an estimated $31.8M added.
- The largest Structure Therapeutics seller in Q1 2025 was Capital Research Global Investors, an estimated $33.6M sold.
Based on aggregated 13F filings for Q1 2025.