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Structure Therapeutics
GPCR

156 hedge funds and large institutions have $1.58B invested in Structure Therapeutics in 2025 Q3 according to their latest regulatory filings, with 22 funds opening new positions, 58 increasing their positions, 48 reducing their positions, and 37 closing their positions.

New
Increased
Maintained
Reduced
Closed

54% more call options, than puts

Call options by funds: $30.2M | Put options by funds: $19.7M

40% more capital invested

Capital invested by funds: $1.13B → $1.58B (+$449M)

21% more repeat investments, than reductions

Existing positions increased: 58 | Existing positions reduced: 48

3.03% more ownership

Funds ownership: 95.31% → 98.33% (+3%)

0% more funds holding in top 10

Funds holding in top 10: 3 → 3 (0)

9% less funds holding

Funds holding: 172 → 156 (-16)

41% less first-time investments, than exits

New positions opened: 22 | Existing positions closed: 37

Holders
156
Holders Change
-16
Holders Change %
-9.3%
% of All Funds
2.05%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.04%
New
22
Increased
58
Reduced
48
Closed
37
Calls
$30.2M
Puts
$19.7M
Net Calls
+$10.6M
Net Calls Change
+$8.63M

Top Buyers

Rank Fund Capital Flow
1
ACA
Avoro Capital Advisors
New York
+$103M
2
BI
BVF Inc
California
+$28.5M
3
SL
Siren LLC
Connecticut
+$20.5M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$9.19M
5
PBA
Paradigm Biocapital Advisors
New York
+$7.43M

Top Sellers

Rank Fund Capital Flow
1
Capital International Investors
Capital International Investors
California
-$33.6M
2
VPC
Vestal Point Capital
New York
-$24.9M
3
Wellington Management Group
Wellington Management Group
Massachusetts
-$23.6M
4
BBA
Baker Bros. Advisors
New York
-$19M
5
DTC
Deep Track Capital
Connecticut
-$18.3M
Name Holding Trade Value Shares
Change 		Change in
Stake
Bessemer Group
151
Bessemer Group
New Jersey
$1K +$578 +29 New
GRP
152
Global Retirement Partners
California
$280 – – –
CFB
153
Cullen/Frost Bankers
Texas
$224 – – –
LFG
154
Larson Financial Group
Missouri
$84 +$60 +3 New
HNB
155
Huntington National Bank
Ohio
$56 – – –
PAS
156
Point72 Asia (Singapore)
Singapore
$28 – – –
Capital International Investors
157
Capital International Investors
California
– -$33.6M -1,618,876 Closed
VPC
158
Vestal Point Capital
New York
– -$24.9M -1,200,000 Closed
SSA
159
Schonfeld Strategic Advisors
New York
– -$6.67M -321,591 Closed
FCMV
160
Foresite Capital Management VI
California
– -$4.36M -210,000 Closed
Marshall Wace
161
Marshall Wace
United Kingdom
– -$3.65M -176,060 Closed
SCM
162
Silverarc Capital Management
Massachusetts
– -$3.64M -175,636 Closed
Canada Pension Plan Investment Board
163
Canada Pension Plan Investment Board
Ontario, Canada
– -$3.48M -167,800 Closed
JG
164
Jain Global
New York
– -$1.44M -69,369 Closed
EAM
165
Exome Asset Management
New York
– -$1.11M -53,744 Closed
SI
166
Sofinnova Investments
California
– -$712K -34,353 Closed
DA
167
DCF Advisers
Connecticut
– -$513K -24,750 Closed
OAC
168
OMERS Administration Corp
Ontario, Canada
– -$510K -24,600 Closed
NIM
169
NEOS Investment Management
Connecticut
– -$475K -22,880 Closed
TE
170
Tema ETFs
New York
– -$475K -22,880 Closed
TC
171
Tejara Capital
United Kingdom
– -$465K -22,400 Closed
PP
172
Paloma Partners
Connecticut
– -$435K -20,950 Closed
PCM
173
Prelude Capital Management
New York
– -$354K -17,070 Closed
QC
174
Quadrature Capital
United Kingdom
– -$334K -16,079 Closed
Squarepoint
175
Squarepoint
New York
– -$315K -15,176 Closed
4 5 6
7
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GPCR Hedge Fund Activity: Q3 2025 in Review

156 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Structure Therapeutics (GPCR) for Q3 2025, worth a combined $1.58B — up 40% from $1.13B a quarter earlier.

Sellers outnumbered buyers: 37 funds closed out of GPCR and 22 opened new positions — a net loss of 15 holders — while 48 trimmed existing stakes and 58 added.

The largest buyer was Avoro Capital Advisors, opening a new position worth an estimated $103M. The largest seller was Capital International Investors, exiting entirely with an estimated $33.6M sold.

  • 156 institutional investors held Structure Therapeutics (GPCR) as of Q3 2025, down from 172 in Q2 2025.
  • Funds reported $1.58B of Structure Therapeutics stock for Q3 2025, up 40% quarter-over-quarter.
  • 22 funds opened new Structure Therapeutics positions in Q3 2025 and 37 closed out, a net change of -15 holders.
  • The largest Structure Therapeutics buyer in Q3 2025 was Avoro Capital Advisors, an estimated $103M added.
  • The largest Structure Therapeutics seller in Q3 2025 was Capital International Investors, an estimated $33.6M sold.

Based on aggregated 13F filings for Q3 2025.