Structure Therapeutics
GPCR
156 hedge funds and large institutions have $1.58B invested in Structure Therapeutics in 2025 Q3 according to their latest regulatory filings, with 22 funds opening new positions, 58 increasing their positions, 48 reducing their positions, and 37 closing their positions.
54% more call options, than puts
Call options by funds: $30.2M | Put options by funds: $19.7M
40% more capital invested
Capital invested by funds: $1.13B → $1.58B (+$449M)
21% more repeat investments, than reductions
Existing positions increased: 58 | Existing positions reduced: 48
3.03% more ownership
Funds ownership: 95.31% → 98.33% (+3%)
0% more funds holding in top 10
Funds holding in top 10: 3 → 3 (0)
9% less funds holding
Funds holding: 172 → 156 (-16)
41% less first-time investments, than exits
New positions opened: 22 | Existing positions closed: 37
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
ACA
Avoro Capital Advisors
New York
|
+$103M |
| 2 |
BI
BVF Inc
San Francisco,
California
|
+$28.5M |
| 3 |
SL
Siren LLC
Greenwich,
Connecticut
|
+$20.5M |
| 4 |
Balyasny Asset Management
Chicago,
Illinois
|
+$9.19M |
| 5 |
PBA
Paradigm Biocapital Advisors
New York
|
+$7.43M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Capital International Investors
Los Angeles,
California
|
-$33.6M |
| 2 |
VPC
Vestal Point Capital
New York
|
-$24.9M |
| 3 |
Wellington Management Group
Boston,
Massachusetts
|
-$23.6M |
| 4 |
BBA
Baker Bros. Advisors
New York
|
-$19M |
| 5 |
DTC
Deep Track Capital
Greenwich,
Connecticut
|
-$18.3M |
GPCR Hedge Fund Activity: Q3 2025 in Review
156 of the 7,620 institutional investors tracked by Wall St. Rank reported a position in Structure Therapeutics (GPCR) for Q3 2025, worth a combined $1.58B — up 40% from $1.13B a quarter earlier.
Sellers outnumbered buyers: 37 funds closed out of GPCR and 22 opened new positions — a net loss of 15 holders — while 48 trimmed existing stakes and 58 added.
The largest buyer was Avoro Capital Advisors, opening a new position worth an estimated $103M. The largest seller was Capital International Investors, exiting entirely with an estimated $33.6M sold.
- 156 institutional investors held Structure Therapeutics (GPCR) as of Q3 2025, down from 172 in Q2 2025.
- Funds reported $1.58B of Structure Therapeutics stock for Q3 2025, up 40% quarter-over-quarter.
- 22 funds opened new Structure Therapeutics positions in Q3 2025 and 37 closed out, a net change of -15 holders.
- The largest Structure Therapeutics buyer in Q3 2025 was Avoro Capital Advisors, an estimated $103M added.
- The largest Structure Therapeutics seller in Q3 2025 was Capital International Investors, an estimated $33.6M sold.
Based on aggregated 13F filings for Q3 2025.