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Structure Therapeutics
GPCR

156 hedge funds and large institutions have $1.58B invested in Structure Therapeutics in 2025 Q3 according to their latest regulatory filings, with 22 funds opening new positions, 58 increasing their positions, 48 reducing their positions, and 37 closing their positions.

New
Increased
Maintained
Reduced
Closed

54% more call options, than puts

Call options by funds: $30.2M | Put options by funds: $19.7M

40% more capital invested

Capital invested by funds: $1.13B → $1.58B (+$449M)

21% more repeat investments, than reductions

Existing positions increased: 58 | Existing positions reduced: 48

3.03% more ownership

Funds ownership: 95.31% → 98.33% (+3%)

0% more funds holding in top 10

Funds holding in top 10: 3 → 3 (0)

9% less funds holding

Funds holding: 172 → 156 (-16)

41% less first-time investments, than exits

New positions opened: 22 | Existing positions closed: 37

Holders
156
Holders Change
-16
Holders Change %
-9.3%
% of All Funds
2.05%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.04%
New
22
Increased
58
Reduced
48
Closed
37
Calls
$30.2M
Puts
$19.7M
Net Calls
+$10.6M
Net Calls Change
+$8.63M

Top Buyers

Rank Fund Capital Flow
1
ACA
Avoro Capital Advisors
New York
+$103M
2
BI
BVF Inc
California
+$28.5M
3
SL
Siren LLC
Connecticut
+$20.5M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$9.19M
5
PBA
Paradigm Biocapital Advisors
New York
+$7.43M

Top Sellers

Rank Fund Capital Flow
1
Capital International Investors
Capital International Investors
California
-$33.6M
2
VPC
Vestal Point Capital
New York
-$24.9M
3
Wellington Management Group
Wellington Management Group
Massachusetts
-$23.6M
4
BBA
Baker Bros. Advisors
New York
-$19M
5
DTC
Deep Track Capital
Connecticut
-$18.3M
Name Holding Trade Value Shares
Change 		Change in
Stake
Handelsbanken Fonder
51
Handelsbanken Fonder
Sweden
$4.7M -$4.22M -212,000 -56%
EP
52
Eversept Partners
New York
$4.66M +$1.34M +67,053 +67%
HH
53
HSG Holding
Hong Kong
$4.61M – – –
IC
54
Ikarian Capital
Texas
$4.57M -$395K -19,848 -11%
Renaissance Technologies
55
Renaissance Technologies
New York
$4.31M +$837K +42,000 +38%
National Bank of Canada
56
National Bank of Canada
Quebec, Canada
$4.03M +$2.86M +143,800 +71,900%
SC
57
Stempoint Capital
New York
$3.62M +$2.58M +129,335 New
PIM
58
Platinum Investment Management
Australia
$3.44M +$953K +47,858 +64%
PE
59
Point72 Europe
United Kingdom
$3.27M – – –
PHS
60
PFM Health Sciences
California
$3.22M +$1.16M +58,479 +103%
OCA
61
Octagon Capital Advisors
New York
$3.22M +$2.29M +115,000 New
JF
62
Jump Financial
Illinois
$2.98M +$860K +43,166 +68%
SFI
63
Susquehanna Fundamental Investments
Pennsylvania
$2.79M -$799K -40,100 -29%
BNP Paribas Financial Markets
64
BNP Paribas Financial Markets
France
$2.53M +$490K +24,595 +37%
BC
65
Birchview Capital
Vermont
$2.18M +$837K +42,000 +117%
WP
66
Woodline Partners
California
$1.83M -$2.21M -111,013 -63%
BPC
67
Banque Pictet & Cie
Switzerland
$1.8M -$124K -6,216 -9%
Bank of Montreal
68
Bank of Montreal
Ontario, Canada
$1.7M +$52.8K +2,649 +5%
DCM
69
DAFNA Capital Management
California
$1.65M – – –
ETC
70
Exchange Traded Concepts
Oklahoma
$1.63M -$69.9K -3,510 -6%
JP Morgan Chase
71
JP Morgan Chase
New York
$1.63M +$313K +15,706 +37%
Macquarie Group
72
Macquarie Group
Australia
$1.62M – – –
Geode Capital Management
73
Geode Capital Management
Massachusetts
$1.62M +$75.2K +3,777 +7%
CM
74
Caption Management
Oklahoma
$1.59M +$568K +28,508 +101%
SPS
75
Susquehanna Portfolio Strategies
Pennsylvania
$1.57M +$318K +15,982 +40%
1 2
3
4 5

GPCR Hedge Fund Activity: Q3 2025 in Review

156 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Structure Therapeutics (GPCR) for Q3 2025, worth a combined $1.58B — up 40% from $1.13B a quarter earlier.

Sellers outnumbered buyers: 37 funds closed out of GPCR and 22 opened new positions — a net loss of 15 holders — while 48 trimmed existing stakes and 58 added.

The largest buyer was Avoro Capital Advisors, opening a new position worth an estimated $103M. The largest seller was Capital International Investors, exiting entirely with an estimated $33.6M sold.

  • 156 institutional investors held Structure Therapeutics (GPCR) as of Q3 2025, down from 172 in Q2 2025.
  • Funds reported $1.58B of Structure Therapeutics stock for Q3 2025, up 40% quarter-over-quarter.
  • 22 funds opened new Structure Therapeutics positions in Q3 2025 and 37 closed out, a net change of -15 holders.
  • The largest Structure Therapeutics buyer in Q3 2025 was Avoro Capital Advisors, an estimated $103M added.
  • The largest Structure Therapeutics seller in Q3 2025 was Capital International Investors, an estimated $33.6M sold.

Based on aggregated 13F filings for Q3 2025.