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Structure Therapeutics
GPCR

Overview Fund Activity

151 hedge funds and large institutions have $981M invested in Structure Therapeutics in 2025 Q1 according to their latest regulatory filings, with 24 funds opening new positions, 46 increasing their positions, 50 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
151
Holders Change
-12
Holders Change %
-7.36%
% of All Funds
2.05%
Holding in Top 10
1
Holding in Top 10 Change
-4
Holding in Top 10 Change %
-80%
% of All Funds
0.01%
New
24
Increased
46
Reduced
50
Closed
35
Calls
$12.4M
Puts
$11.7M
Net Calls
+$750K
Net Calls Change
-$10.1M

Top Buyers

1
DTC
1
Deep Track Capital
Connecticut
$71M
2
Morgan Stanley
2
Morgan Stanley
New York
$12M
3
RAM
3
Readystate Asset Management
Illinois
$8.33M
4
Janus Henderson Group
4
Janus Henderson Group
United Kingdom
$86.1M
5
Handelsbanken Fonder
5
Handelsbanken Fonder
Sweden
$6.58M

Top Sellers

1
Capital Research Global Investors
1
Capital Research Global Investors
California
$37.5M
2
Federated Hermes
2
Federated Hermes
Pennsylvania
$20.3M
3
DCM
3
Driehaus Capital Management
Illinois
$22M
4
BCM
4
Boxer Capital Management
California
$0
5
T. Rowe Price Associates
5
T. Rowe Price Associates
Maryland
$13.5M
Name Holding Trade Value Shares
Change 		Shares
Change %
CWM
51
CCG Wealth Management
California
$2.6M – – –
JPMorgan Chase & Co
52
JPMorgan Chase & Co
New York
$2.32M +$1.76M +101,924 +315%
FLAM
53
First Light Asset Management
Minnesota
$2.29M -$4.61M -266,475 -67%
Jane Street
54
Jane Street
New York
$2.09M +$81.2K +4,690 +4%
TI
55
Trexquant Investment
Connecticut
$2.08M +$1.17M +67,464 +128%
Citigroup
56
Citigroup
New York
$1.82M +$535K +30,891 +42%
EAM
57
Exome Asset Management
New York
$1.78M -$849K -49,021 -32%
ZP
58
Zimmer Partners
New York
$1.74M +$759K +43,876 +77%
PE
59
Point72 Europe
United Kingdom
$1.57M +$1.03M +59,277 +189%
SFM
60
Sphera Funds Management
Israel
$1.45M +$1.45M +84,000 New
BPC
61
Banque Pictet & Cie
Switzerland
$1.42M +$131K +7,589 +10%
Capital Fund Management (CFM)
62
Capital Fund Management (CFM)
France
$1.38M +$217K +12,521 +19%
BFM
63
Boothbay Fund Management
New York
$1.34M -$101K -5,854 -7%
Universal-Beteiligungs- und Servicegesellschaft
64
Universal-Beteiligungs- und Servicegesellschaft
Germany
$1.33M -$643K -37,129 -33%
PIM
65
Platinum Investment Management
Australia
$1.3M – – –
RPAM
66
Rhenman & Partners Asset Management
Sweden
$1.21M +$1.21M +70,000 New
Susquehanna International Group
67
Susquehanna International Group
Pennsylvania
$1.18M -$623 -36 -0.1%
DCM
68
DAFNA Capital Management
California
$1.02M +$407K +23,500 +66%
Macquarie Group
69
Macquarie Group
Australia
$1M – – –
Bank of America
70
Bank of America
North Carolina
$960K +$21.7K +1,253 +2%
CSS
71
Cubist Systematic Strategies
Connecticut
$949K +$949K +54,816 New
Bank of Montreal
72
Bank of Montreal
Ontario, Canada
$921K +$53K +3,062 +6%
Group One Trading
73
Group One Trading
Illinois
$847K +$473K +27,350 +127%
Geode Capital Management
74
Geode Capital Management
Massachusetts
$792K +$554 +32 +0.1%
TD Asset Management
75
TD Asset Management
Ontario, Canada
$756K -$782K -45,196 -51%
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